Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA
dc.cclicence | N/A | en |
dc.contributor.author | Weldon, Carika | en |
dc.contributor.author | Behm-Ansmant, Isabelle | en |
dc.contributor.author | Hurley, Laurence H. | en |
dc.contributor.author | Burley, Glenn A. | en |
dc.contributor.author | Branlant, Christiane | en |
dc.contributor.author | Eperon, Ian C. | en |
dc.contributor.author | Dominguez, Cyril | en |
dc.date.acceptance | 2016-08-31 | en |
dc.date.accessioned | 2017-10-31T12:58:38Z | |
dc.date.available | 2017-10-31T12:58:38Z | |
dc.date.issued | 2016-11-07 | |
dc.description.abstract | RNA G-quadruplex (G4) structures are thought to affect biological processes, including translation and pre-mRNA splicing, but it is not possible at present to demonstrate that they form naturally at specific sequences in long functional RNA molecules. We developed a new strategy, footprinting of long 7-deazaguanine-substituted RNAs (FOLDeR), that allows the formation of G4s to be confirmed in long RNAs and under functional conditions. | en |
dc.exception.ref2021codes | 254a | en |
dc.funder | Sir Dudley Spurling Post Graduate Scholarship | en |
dc.funder | Medical Research Council Career Development Award | en |
dc.funder | CNRS and Lorraine University | en |
dc.funder | European Alternative Splicing Network of Excellence | en |
dc.identifier.citation | Weldon, C. et al. (2017) Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA. Nature Chemical Biology, 13, pp. 18-20 | en |
dc.identifier.doi | https://doi.org/10.1038/nchembio.2228 | |
dc.identifier.uri | http://hdl.handle.net/2086/14769 | |
dc.language.iso | en | en |
dc.peerreviewed | Yes | en |
dc.projectid | G1000526 | en |
dc.projectid | UMR 7365 and previously 7214 | en |
dc.projectid | LSHG-CT-2005-518238 | en |
dc.publisher | Nature Publishing Group | en |
dc.subject | G-quadruplexes | en |
dc.subject | Chemical tools | en |
dc.subject | RNA splicing | en |
dc.title | Identification of G-quadruplexes in long functional RNAs using 7-deazaguanine RNA | en |
dc.type | Article | en |