Fluroacetate.

Action of fluoroacetate (FA) becomes apparent after a latent period, even after exposure to lethal doses. The best known representative of FA is its sodium salt. There are also series of fluorinated compounds which metabolism is connected with formation of FA. To reveal intoxications, adequate analytical procedures should be developed, as well as unequivocal biochemical, physiological and clinical signs of intoxication should be described. Also, new approaches to development of an effective therapy for treating acute intoxications by FA are highly important, because after many decades of toxicological studies on FA effective antidotes are not available. These and other points are the subjects of discussion in this chapter. Some old and new data are critically revised, together with presentation of the authors’ experimental results, the main theme of which is development of new and effective therapy for treating acute intoxication by FA.