A therapeutic update on PARP inhibitors: implications in the treatment of glioma
Date
2020-11-04
Authors
Advisors
Journal Title
Journal ISSN
ISSN
Volume Title
Publisher
Elsevier
Type
Article
Peer reviewed
Yes
Abstract
Central nervous system (CNS) cancers are among the most aggressive and devastating. Furthermore, because of the lack of neuro-oncologists and neurosurgeons in many parts of the world, the specialized treatment options of CNS cancers are not fully available worldwide. Among various strategies of inducing death in cancer cells, inhibition of poly(ADP-ribose)polymerase (PARP) has emerged as a beneficial therapy when combined with other anticancer agents. In this review, we provide a detailed therapeutic update of PARP inhibitors (PARPis) that have shown clinical activity against glioma.
Description
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.
Keywords
glioma, PARP inhibitors, chemotherapy
Citation
Lal, S., Snape, T. (2020) A therapeutic update on PARP inhibitors: implications in the treatment of glioma. Drug Discovery Today,