Controlled Engineering of Highly Aligned Fibrous Dosage Form Matrices for Controlled Release

Files

Revised Manuscript (002).docx (3.66 MB)

Date

2018-08-20

Authors

Wu, Shuting
Ahmad, Z.
Li, Jing-Song
Chang, Ming-Wei

Advisors

Journal Title

Journal ISSN

ISSN

DOI

https://doi.org/10.1016/j.matlet.2018.08.101

Volume Title

Publisher

Elsevier

Type

Article

Peer reviewed

Yes

Abstract

In this study, complex drug-cellulose acetate (CA) composite films were designed and fabricated possessing pre-determined grid spacing for inter-connected fibrous films. Ibuprofen (IBU) was selected as the active ingredient. and grid spacing was varied between 300 to 500μm (fiber diameter~35μm) for various geometries. Process parameter impact on fiber morphology and deposition was investigated. FTIR confirmed IBU encapsulation and XRD analysis indicated the drug was dispersed (amorphous) in films. Inter-connected grid void geometry was shown to impact water contact behavior, and drug release mechanism was shown to be Fickian diffusion. Furthermore, drug release rate depended on geometry of engineered structures. The findings suggest a spatial design approach for modulated drug release from bespoke drug delivery dosage forms.

Description

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.

Keywords

biomaterials, patterning, microstructure, controlled release, electrohydrodynamic printing

Citation

Wu, S., Ahmad, Z., Li, J.-S. and Chang, M-W. (2018) Controlled Engineering of Highly Aligned Fibrous Dosage Form Matrices for Controlled Release. Materials Letters, 232, pp. 134-137

URI

http://hdl.handle.net/2086/16512

Rights

Research Institute

Collections

Leicester School of Pharmacy