Enhancing the antibacterial effect of chitosan to combat orthopaedic implant-associated infections.

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dc.contributor.authorRahayu, Dien Puji
dc.contributor.authorDe Mori, Arianna
dc.contributor.authorYusuf, Rahmi
dc.contributor.authorDraheim, Roger
dc.contributor.authorLalatsa, Aikaterini
dc.contributor.authorRoldo, Marta
dc.date.accessioned2024-09-24T14:01:37Z
dc.date.available2024-09-24T14:01:37Z
dc.date.issued2022-03-28
dc.descriptionopen access article SDG3
dc.description.abstractThe development of antibacterial resistance imposes the development of novel materials to relieve the burden of infection. Chitosan, a material of natural and sustainable origin, possesses ideal characteristics to translate into a novel biomaterial with antibacterial properties, as it already has these properties and it allows easy and scalable chemical modification to enhance its activity. The aim of the present work was that of producing low molecular weight chitosans that have higher solubility and can remain protonated at physiological pH, thus enhancing the antimicrobial action. This was achieved by reacting acid hydrolysed low molecular weight chitosan with 2-bromoethyleneamine hydrobromide or Fmoc-Lys(Fmoc)-OH to elicit N-(2-ethylamino)-chitosan and N-2(2,6-diaminohexanamide)-chitosan polymers. The latter derivative, CS3H Lys, that was synthesised for the first time, showed superior efficacy against Staphylococcus aureus, supporting further studies for its inclusion in implant coating materials to tackle the burden of orthopaedic implant-associated infections.
dc.funderOther external funder (please detail below)
dc.funder.otherRISET-Pro by the Ministry of Research, Technology and Higher Education of the Republic of Indonesia
dc.identifier.citationRahayu, D.P. et al. (2022)Enhancing the antibacterial effect of chitosan to combat orthopaedic implant-associated infections. Carbohydrate Polymers, 289, 119385
dc.identifier.doihttps://doi.org/10.1016/j.carbpol.2022.119385
dc.identifier.urihttps://hdl.handle.net/2086/24257
dc.language.isoen
dc.peerreviewedYes
dc.projectid8245-ID
dc.publisherElsevier
dc.researchinstitute.instituteLeicester Institute for Pharmaceutical and Health Innovations
dc.rightsAttribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectAntibacterial activity
dc.subjectChitosan
dc.subjectChitosan derivatives
dc.subjectImplant-associated infection
dc.subjectS. aureus
dc.titleEnhancing the antibacterial effect of chitosan to combat orthopaedic implant-associated infections.
dc.typeArticle

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