High resolution LC-ToF mass spectrometry data used for drug monitoring in clinical applications using dried blood spot samples

Simple item page
dc.contributor.authorLawson, Grahamen
dc.contributor.authorTanna, Sangeetaen
dc.date.accessioned2015-09-16T08:41:59Z
dc.date.available2015-09-16T08:41:59Z
dc.date.issued2015-09-08
dc.description.abstractQuantitative dried blood spot (DBS) analysis was used to investigate if the accurate mass capability (±2ppm m/z) of high resolution mass spectrometry (HRMS) would provide compound specificity comparable to the multiple reaction monitoring (mrm) approach used with a triple quadrupole mass spectrometer. Dried blood spots are now widely used for microsampling in clinical investigations and in this study the determination of atenolol, caffeine, captopril and dexamethasone in DBS samples was carried out using liquid chromatography-high resolution mass spectrometry. Some initial pharmacokinetic results from therapeutic drug monitoring data obtained from the DBS samples is reported.en
dc.funderHEIFen
dc.identifier.citationLawson, G. and Tanna, S. (2015) High resolution LC-ToF mass spectrometry data used for drug monitoring in clinical applications using dried blood spot samples. Proceedings of the Second Annual European Congress for Mass Spectrometry: Applications to the Clinical Lab, September 8-11, Salzburg, Austriaen
dc.identifier.urihttp://hdl.handle.net/2086/11203
dc.language.isoenen
dc.peerreviewedYesen
dc.projectidblood spot analysis researchen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.subjectLC-HRMSen
dc.subjectdried blood spoten
dc.subjectLC-ToF MSen
dc.subjectquantificationen
dc.subjecttherapeutic drug monitoringen
dc.titleHigh resolution LC-ToF mass spectrometry data used for drug monitoring in clinical applications using dried blood spot samplesen
dc.typeConferenceen

Files

License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Leicester School of Pharmacy