Semipermeable poly(ethylene glycol) films: the relationship between permeability and molecular structure of polymer chains

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dc.contributor.authorSchlapak, Robert
dc.contributor.authorArmitage, David
dc.contributor.authorCaruana, D.
dc.contributor.authorHoworka, Stefan
dc.date.accessioned2010-01-12T11:12:29Z
dc.date.available2010-01-12T11:12:29Z
dc.date.issued2009
dc.description.abstractWe describe size-selective semipermeable poly(ethylene glycol) (PEG) films which avoid the nonspecific absorption of large proteins but permit the passage of small target molecules. The size threshold for permeation through the PEG films on indium-tin oxide surfaces was characterised using cyclovoltammetry and redox-active probes of 0.3 and 0.6 nm diameter. The permeation was dependent on the molecular weight of PEG and the different conformational preferences of the polymer chains. PEG 5000 D with a looped and dynamically changing structure provided a porous and easily permeable meshwork for the passage of small molecules. In contrast, parallel aligned and helical PEG 500 chains represented a denser molecular sieve which is only permeable for small molecules 0.3 nm in size. By describing the relationship between the molecular structure and an important physiochemical property of surface-tethered PEG films, our findings on controllable semipermeable interfaces may be exploited for electrical sensor surfaces.en
dc.description.sponsorshipAustrian Science Foundation N00104-NANen
dc.identifier.citationSchlapak, R., Armitage, D., Caruana, D. and Howorka, S. (2009) Semipermeable poly(ethylene glycol) films: the relationship between permeability and molecular structure of polymer chains. Soft Matter, 5, pp.4104-4112.en
dc.identifier.doihttps://doi.org/10.1039/b913836f
dc.identifier.issn1744-683X
dc.identifier.urihttp://hdl.handle.net/2086/3205
dc.language.isoenen
dc.peerreviewedYesen
dc.publisherRoyal Society of Chemistryen
dc.researchgroupPharmaceutical Technologies
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.subjectself assembled monolayersen
dc.subjectIndium-Tin oxideen
dc.subjectprotein surface interactionsen
dc.subjectpolyethylene-glycolen
dc.subjectelectrochemical controlen
dc.subjectoligo(ethylene glycol)en
dc.subjectforce microscopyen
dc.subjectglass surfacesen
dc.subjectthin-filmsen
dc.subjectadsorptionen
dc.titleSemipermeable poly(ethylene glycol) films: the relationship between permeability and molecular structure of polymer chainsen
dc.typeArticleen

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