Effect of lubricants on the properties of tablets compressed from varied size granules

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dc.contributor.authorHackl, E.
dc.contributor.authorErmolina, I.
dc.contributor.authorKabova, E.
dc.date.acceptance2023-08-01
dc.date.accessioned2025-02-10T13:51:56Z
dc.date.available2025-02-10T13:51:56Z
dc.date.issued2023-12-30
dc.descriptionopen access article
dc.description.abstractMagnesium stearate (MgSt) is one of the most widely used solid lubricants in oral solid dosage forms. However, MgSt can negatively impact the tablets, decreasing their mechanical properties and lengthening disintegration/dissolution times. The aim of the present study was to compare the effect of MgSt and Sodium Stearyl Fumarate (SSF) lubricants on the physical characteristics of immediate release caffeine tablets compressed using granules of different sizes. Overall, the results demonstrate that using SSF as a lubricant significantly enhances tablet mechanical strength and reduces disintegration/wetting times for all granule sizes used to compress tablets. With smaller granules, SSF tends to be more effective. Over-lubrication with SSF leads to a decrease in tablet hardness as well, though to a significantly lesser extent than over-lubrication with MgSt.
dc.funderNo external funder
dc.identifier.citationHackl, E., Ermolina, I. and Kabova, E. (2023) Effect of lubricants on the properties of tablets compressed from varied size granules. British Journal of Pharmacy, 8 (2), 1395
dc.identifier.doihttps://doi.org/10.5920/bjpharm.1395
dc.identifier.urihttps://hdl.handle.net/2086/24781
dc.language.isoen
dc.peerreviewedYes
dc.publisherUniversity of Huddersfield Press
dc.relation.ispartofseriesv8(2), article 1395
dc.researchinstitute.instituteLeicester Institute for Pharmaceutical and Health Innovations
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectlubricant
dc.subjectmagnesium stearate
dc.subjectsodium stearyl fumarate
dc.subjecttablet hardness
dc.titleEffect of lubricants on the properties of tablets compressed from varied size granules
dc.typeArticle

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