Supplement therapy with apelin for improving the TSH level and lipid disorders in PTU-induced hypothyroid rats.

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dc.contributor.authorBadavi, M.
dc.contributor.authorGrootveld, Martin
dc.contributor.authorJafari, F.
dc.contributor.authorDianat, M.
dc.contributor.authorShahrivar, F.
dc.date.acceptance2021-03-04
dc.date.accessioned2024-10-29T13:20:57Z
dc.date.available2024-10-29T13:20:57Z
dc.date.issued2021-03-04
dc.description.abstractHyperlipidemia is a common metabolic disorder in the general population, which may arise in hypothyroidism. Apelin is an endogenous ligand that acts as an adiponectin, and is involved in energy storage and metabolism. This study evaluated the effects of apelin administration per se or in combination with T4 on the serum level of thyroid-stimulating hormone (TSH), body weight, and lipid profile, along with the serum level of apelin, and its mRNA expression in heart, in 6-propyl-2-thiouracil (PTU)-induced hypothyroid rats. Male Wistar rats were assigned to five different groups: control, H (hypothyroid), H+A, H+T, and H+A+T. All groups except the control one received PTU (0.05%) in the drinking water for 6 weeks. In addition to PTU, the H+A, H+T, and H+A+T groups received apelin (200 μg/kg/day, i.p.), l-thyroxin (T4) (20 μg/kg/day, via gavage tube), and apelin+T4 during the last 14 days of the trial, respectively. A combined application of T4 and apelin in the H+A+T group effectively diminished mean TSH level, low-density-lipoprotein cholesterol/high-density-lipoprotein cholesterol ratio, and atherogenic index in these animals when compared with these values for the H group. Coadministration of apelin with T4 may offer valuable therapeutic benefits, specifically lowering blood plasma TSH, lipid disorder, and atherosclerosis biomarkers in PTU-induced hypothyroid rats.
dc.exception.reasonnot deposited within three months of publication
dc.funderNo external funder
dc.identifier.citationBadavi, M., Grootveld, M., Jafari, F., Dianat, M., Shahrivar, F. (2022) Supplement therapy with apelin for improving the TSH level and lipid disorders in PTU-induced hypothyroid rats. Biotechnology and Applied Biochemistry, 69 (2), pp. 668-675
dc.identifier.doihttps://doi.org/10.1002/bab.2142
dc.identifier.urihttps://hdl.handle.net/2086/24409
dc.language.isoen
dc.peerreviewedYes
dc.publisherIUBMB Publications
dc.researchinstitute.instituteLeicester Institute for Pharmaceutical and Health Innovations
dc.subjectHyperlipidemia
dc.subjecthypothyroidism
dc.subjectapelin
dc.subjectthyroxine
dc.subjectTSH
dc.subjectmetabolic disorders
dc.subject6-propyl-2-thiouracil
dc.titleSupplement therapy with apelin for improving the TSH level and lipid disorders in PTU-induced hypothyroid rats.
dc.typeArticle

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