An Interactional Profile to Assist the Differential Diagnosis of Neurodegenerative and Functional Memory Disorders

dc.cclicenceCC-BY-NCen
dc.contributor.authorReuber, Markusen
dc.contributor.authorBlackburn, Danielen
dc.contributor.authorElsey, Christopheren
dc.contributor.authorWakefield, Sarahen
dc.contributor.authorArden, Kerryen
dc.contributor.authorHarkness, Kirstyen
dc.contributor.authorVenneri, Annalenaen
dc.contributor.authorJones, Danielleen
dc.contributor.authorShaw, Chloeen
dc.contributor.authorDrew, Paulen
dc.date.acceptance2017-10-26en
dc.date.accessioned2018-06-07T14:28:18Z
dc.date.available2018-06-07T14:28:18Z
dc.date.issued2018-01-09
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.en
dc.description.abstractObjective: Specialist services for dementia are seeing an increasing number of patients. We investigated whether interactional and linguistic features in the communication behaviour of patients with memory problems could help distinguish between those with problems secondary to neurological disorders (ND) and those with Functional Memory Disorder (FMD). Methods: In Part 1 of this study, a Diagnostic Scoring Aid (DSA) was developed encouraging linguists to provide quantitative ratings for 14 interactional features. An optimal cut-off differentiating ND and FMD was established by applying the DSA to 30 initial patient–doctor memory clinic encounters. In Part 2, the DSA was tested prospectively in ten additional cases analysed independently by two Conversation Analysts blinded to medical information. Results: In part one, the median score of the DSA was +5 in ND and -5 in FMD (p<0.001). The optimal numeric DSA cut off (+1) identified patients with ND with a sensitivity of 86.7% and a specificity of 100%. In part two, DSA scores of rater one correctly predicted 10/10 and those of rater two 9/10 diagnoses. Conclusions This study indicates that interactional and linguistic features can help distinguish between patients developing dementia and those with FMD and could aid the stratification of patients with memory problems.en
dc.funderNational Institute for Health Research (NIHR) under its Research for Patient Benefit (RfPB) Programmeen
dc.identifier.citationREUBER, M., BLACKBURN, D. J., ELSEY, C., WAKEFIELD, S., ARDERN, K. A., HARKNESS, K., VENNERI, A., JONES, D., SHAW, C. and DREW, P. (2018) An Interactional Profile to Assist the Differential Diagnosis of Neurodegenerative and Functional Memory Disorders. Alzheimer Disease & Associated Disorders, 32 (3), pp. 197-206en
dc.identifier.doihttps://doi.org/10.1097/wad.0000000000000231
dc.identifier.issn0893-0341
dc.identifier.urihttp://hdl.handle.net/2086/16265
dc.identifier.urihttp://eprints.whiterose.ac.uk/126490/en
dc.language.isoen_USen
dc.peerreviewedYesen
dc.projectidPB-PG-0211-24079en
dc.publisherOviden
dc.researchinstituteInstitute for Allied Health Sciences Researchen
dc.subjectdementiaen
dc.subjectscreeningen
dc.subjectfunctional memory disorderen
dc.titleAn Interactional Profile to Assist the Differential Diagnosis of Neurodegenerative and Functional Memory Disordersen
dc.typeArticleen

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