Menthacarin treatment attenuates nociception in models of visceral hypersensitivity.

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dc.contributor.authorOmoloye, Adesina
dc.contributor.authorWeisenburger, Sabrina
dc.contributor.authorLehner, Martin D.
dc.contributor.authorGronier, Benjamin
dc.date.acceptance2024-01-30
dc.date.accessioned2024-04-08T09:52:17Z
dc.date.available2024-04-08T09:52:17Z
dc.date.issued2024-02-15
dc.descriptionopen access article
dc.description.abstractBackground: Chronic visceral hypersensitivity is closely associated with irritable bowel syndrome (IBS), a very common disorder which significantly impairs quality of life, characterized by abdominal pain, and distension. Imaging studies have found that IBS patients show higher metabolic activities and functional differences from normal controls in the anterior cingulate cortex (ACC), in response to visceral pain stimulation. Non-clinical data and clinical data suggest that medicinal products containing essential oils such as peppermint or caraway oil exert beneficial effects on IBS symptoms. Methods: We assessed acute and long-term treatment effects of a mixture of peppermint and caraway essential oils (Menthacarin) on brain electrophysiological markers of gut pain sensitivity in two rat models of visceral hypersensitivity. Key results: Chronic administration of corticosteroids and acute repeated mechanical hyperstimulation under anesthesia induced hyperalgesia and hypersensitivity, characterized by an increase in electrophysiological excitatory responses of ACC neurons to colorectal distension (CRD) and an increase in the proportion of neurons responding to otherwise subthreshold stimulation, respectively. Long-term, but not acute, oral administration of Menthacarin (60 mg kg-1 day-1) significantly reduced the net excitatory response to CRD in normally responsive control animals and counteracted the development of visceral hyperalgesia and hypersensitivity induced by repeated corticosterone administration and acute mechanical stimulation. Conclusions & inferences: The present study shows that, using the CRD method, chronic Menthacarin administration at a clinically relevant dose attenuates the neuronal discharge associated with visceral pain stimuli in the rat ACC, particularly in models of hypersensitivity, suggesting a potential for treating exaggerated visceral pain sensitivity.
dc.funderOther external funder (please detail below)
dc.funder.otherDr. Willmar Schwabe GmbH & Co
dc.identifier.citationOmoloye, A., Weisenburger, S., Lehner, M.D. and Gronier, B. (2024) Menthacarin treatment attenuates nociception in models of visceral hypersensitivity. Neurogastroenterology & Motility, 36 (4), e14760
dc.identifier.doihttps://doi.org/10.1111/nmo.14760
dc.identifier.issn1365-2982
dc.identifier.urihttps://hdl.handle.net/2086/23674
dc.language.isoen
dc.peerreviewedYes
dc.publisherWiley
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)
dc.rightsAttribution-NonCommercial-NoDerivs 2.0 UK: England & Walesen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/uk/
dc.subjectMenthacarin
dc.subjectanterior cingulate cortex
dc.subjectcolorectal distension
dc.subjectelectrophysiology
dc.subjectirritable bowel syndrome
dc.subjectvisceral hypersensitivity
dc.titleMenthacarin treatment attenuates nociception in models of visceral hypersensitivity.
dc.typeArticle

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