Amorphous solid dispersion formulation of pimobendan for bioavailability enhancement: A comprehensive study on miscibility, interactions, and in vitro dissolution behavior

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dc.contributor.authorQu, Beibei
dc.contributor.authorWu, Hengqian
dc.contributor.authorDing, Zhuang
dc.contributor.authorBu, Rupeng
dc.contributor.authorZheng, Heng
dc.contributor.authorHan, Jun
dc.contributor.authorLi, M.
dc.contributor.authorWang, Zhengping
dc.date.acceptance2025-03-25
dc.date.accessioned2025-04-14T14:15:53Z
dc.date.available2025-04-14T14:15:53Z
dc.date.issued2025-04-03
dc.descriptionopen access article
dc.description.abstractAmorphous solid dispersions (ASDs) of poorly soluble pimobendan (PIMO) in cellulose matrices, including hydroxypropyl methylcellulose acetate succinate (HPMCAS-HG, HPMCAS-MG, HPMCAS-LG), polyvinylpyrrolidone-vinyl acetate (PVPVA64), and polyvinylpyrrolidone (PVPK30), were investigated, aiming to identify the optimal polymer to enhance its solubility and stability of the drug product. The results indicated that the miscibility between PIMO and the selected polymers can be predicted by Hansen solubility parameters and Flory-Huggins interaction parameters, with the ranking order of PVPVA64 > PVPK30 > HPMCAS. Fourier transform infrared (FTIR) spectroscopy analysis revealed significant interactions between PIMO and these polymers. Recrystallization inhibition and dissolution performance were ranked as HPMCAS-HG > HPMCAS-MG > HPMCAS-LG > PVPK30 > PVPVA64. Additionally, the results also indicated that HPMCAS-HG had superior stability compared to PVPVA64 and PVPK30 under elevated humidity, as confirmed by differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD) analysis. These findings provide a theoretical basis for selection of the optimal polymer for design of PIMO ASDs.
dc.funderNo external funder
dc.identifier.citationQu, B., et al. (2025) Amorphous solid dispersion formulation of pimobendan for bioavailability enhancement: A comprehensive study on miscibility, interactions, and in vitro dissolution behavior. Journal of Drug Delivery Science and Technology, 108, 106884
dc.identifier.doihttps://doi.org/10.1016/j.jddst.2025.106884
dc.identifier.urihttps://hdl.handle.net/2086/24952
dc.language.isoen
dc.peerreviewedYes
dc.publisherElsevier
dc.researchinstitute.instituteLeicester Institute for Pharmaceutical and Health Innovations
dc.rightsAttribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectAmorphous solid dispersion
dc.subjectPimobendan
dc.subjectMiscibility
dc.subjectRecrystallization inhibition
dc.subjectDissolution
dc.subjectStability
dc.titleAmorphous solid dispersion formulation of pimobendan for bioavailability enhancement: A comprehensive study on miscibility, interactions, and in vitro dissolution behavior
dc.typeArticle

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