Characterisation of Actions of p-menthane-3,8 diol (PMD) Repellent Formulations against Aedes aegypti mosquitoes
| dc.cclicence | CC-BY-NC | en |
| dc.contributor.author | Goodyer, Larry | |
| dc.contributor.author | Grootveld, Martin | |
| dc.contributor.author | Deobhankar, Kedar | |
| dc.contributor.author | Debboun, Mustapha | |
| dc.contributor.author | Philip, Manju | |
| dc.date.acceptance | 2020-05-19 | |
| dc.date.accessioned | 2020-05-19T14:58:22Z | |
| dc.date.available | 2020-05-19T14:58:22Z | |
| dc.date.issued | 2020-06-15 | |
| dc.description | The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. | en |
| dc.description.abstract | Background Characterisation of mosquito repellents using arm-in-cage tests are performed by assessing the ED95, half-life and complete protection times (CPT). This study fully characterises p-menthane-3,8 diol PMD which has not been widely studied, and a long-acting formulation containing a PMD-vanillin composite. Method A series of arm in cage tests against Aedes aegypti aegypti (Dipera-Culicidae) strain mosquitoes were devised using 6 volunteers to estimate CPT or 10 to estimate the effective dose (ED95) and half-life for three repellents: 20% DEET, 30% PMD and a novel 30% PMD-vanillin formulation. Non-linear Regression analysis was used to characterise the relationship between applied dose and CPT. were also estimated Results PMD and DEET showed a very similar log dose relationship to CPT; however, the PMD-vanillin formulation exhibited a sigmoidal ‘S-shape’ relationship. This resulted in a 1.5 times higher CPT for PMD-vanillin compared to that of 20% DEET when applied at a dose of 1.6mg/cm2, but little difference at lower doses of 0.8-1mg/cm2. The ED95 value for the 30% PMD and PMD-vanillin formulations were 0.25 and 0.24 mg/cm2 respectively, these being higher than that for 20% DEET (0.09 mg/cm2). The half-lives for 30% PMD and 20% DEET were similar (2.23 vs. 2.74 hrs.), but longer for the PMD-vanillin formulations (3.8 hrs.). Conclusion Such a full characterisation for other repellent formulations, particularly those claiming extended longevity, should be conducted in order to identify differences at various applied doses. | en |
| dc.funder | Other external funder (please detail below) | en |
| dc.funder.other | Neo-Innova | en |
| dc.identifier.citation | Goodyer, I.L., Grootveld, M., Deobhankar, K., Debboun, M., Philip, M. (2020) Characterisation of Actions of p-menthane-3,8 diol (PMD) Repellent Formulations against Aedes aegypti mosquitoes. Transactions of The Royal Society of Tropical Medicine and Hygiene, 114 (9), pp. 687-692 | en |
| dc.identifier.doi | https://doi.org/10.1093/trstmh/traa045 | |
| dc.identifier.uri | https://dora.dmu.ac.uk/handle/2086/19623 | |
| dc.language.iso | en | en |
| dc.peerreviewed | Yes | en |
| dc.projectid | N/A | en |
| dc.publisher | Oxford University Press | en |
| dc.researchinstitute | Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI) | en |
| dc.subject | MOSQUITO | en |
| dc.subject | REPELLENT | en |
| dc.subject | DEET | en |
| dc.subject | PMD | en |
| dc.subject | HALF LIFE | en |
| dc.subject | LONGEVITY | en |
| dc.title | Characterisation of Actions of p-menthane-3,8 diol (PMD) Repellent Formulations against Aedes aegypti mosquitoes | en |
| dc.type | Article | en |