Long-term p21 and p53 trends regulate the frequency of mitosis events and cell cycle arrest

dc.cclicenceCC-BYen
dc.contributor.authorTran, Anh Phong
dc.contributor.authorTralie, Christopher
dc.contributor.authorMoosmüller, Caroline
dc.contributor.authorBelkhatir, Zehor
dc.contributor.authorReyes, José
dc.contributor.authorLevine, Arnold
dc.contributor.authorDeasy, Joseph
dc.contributor.authorTannenbaum, Allen
dc.date.accessioned2021-12-16T09:31:54Z
dc.date.available2021-12-16T09:31:54Z
dc.date.issued2021-08-19
dc.description.abstractRadiation exposure of healthy cells can halt cell cycle temporarily or permanently. In this work, two single cell datasets that monitored the time evolution of p21 and p53, one subjected to gamma irradiation and the other to x-ray irradiation, are analyzed to uncover the dynamics of this process. New insights into the biological mechanisms were found by decomposing the p53 and p21 signals into transient and oscillatory components. Through the use of dynamic time warping on the oscillatory components of the two signals, we found that p21 signaling lags behind its lead signal, p53, by about 3.5 hours with oscillation periods of around 6 hours. Additionally, through various quantification methods, we showed how p21 levels, and to a lesser extent p53 levels, dictate whether the cells are arrested in their cell cycle and how fast these cells divide depending on their long-term trend in these signals.en
dc.funderNo external funderen
dc.identifier.citationTran, A. P. et al. (2021) Long-term p21 and p53 trends regulate the frequency of mitosis events and cell cycle arrest. bioRxiven
dc.identifier.doihttps://doi.org/10.1101/2021.08.17.456721
dc.identifier.urihttps://hdl.handle.net/2086/21552
dc.language.isoen_USen
dc.publisherPreprinten
dc.researchinstituteInstitute of Engineering Sciences (IES)en
dc.titleLong-term p21 and p53 trends regulate the frequency of mitosis events and cell cycle arresten
dc.typeOtheren

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