A Molecularly Imprinted Polymer Nanoparticle Based Surface Plasmon Resonance Sensor Platform for Antibiotic Detection in River Water and Milk

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dc.cclicenceCC-BY-NCen
dc.contributor.authorSullivan, Mark
dc.contributor.authorHenderson, Alisha
dc.contributor.authorHand, Rachel
dc.contributor.authorTurner, Nicholas
dc.date.acceptance2022-03-01
dc.date.accessioned2022-08-23T09:17:29Z
dc.date.available2022-08-23T09:17:29Z
dc.date.issued2022-03-23
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.en
dc.description.abstractUsing a solid-phase molecular imprinting technique, high-affinity nanoparticles (nanoMIPs) selective for the target antibiotics, ciprofloxacin, moxifloxacin, and ofloxacin have been synthesised. These have been applied in the development of a surface plasmon resonance (SPR) sensor for the detection of the three antibiotics in both river water and milk. The particles produced demonstrated good uniformity with approximate sizes of 65.8 ± 1.8 nm, 76.3 ± 4.1 nm, and 85.7 ± 2.5 nm, and were demonstrated to have affinities of 36.2 nM, 54.7 nM, and 34.6 nM for the ciprofloxacin, moxifloxacin, and ofloxacin nanoMIPs, respectively. Cross-reactivity studies highlighted good selectivity towards the target antibiotic compared with a non-target antibiotic. Using spiked milk and river water samples, the nanoMIP-based SPR sensor offered comparable affinity with 66.8 nM, 33.4 nM, and 55.0 nM (milk) and 39.3 nM, 26.1 nM, and 42.7 nM (river water) for ciprofloxacin, moxifloxacin, and ofloxacin nanoMIPs, respectively, to that seen within a buffer standard. Estimated LODs for the three antibiotic targets in both milk and river water were low nM or below. The developed SPR sensor showed good potential for using the technology for the capture and detection of antibiotics from food and environmental samples.en
dc.funderNo external funderen
dc.identifier.citationSullivan, M., Henderson, A., Hand, R.A., and Turner N.W. (2022) A molecularly imprinted polymer nanoparticle-based surface plasmon resonance sensor platform for antibiotic detection in river water and milk. Analytical and Bioanalytical Chemistry 414 (12), pp. 3687-3696en
dc.identifier.doihttps://doi.org/10.1007/s00216-022-04012-8
dc.identifier.urihttps://hdl.handle.net/2086/22131
dc.language.isoenen
dc.peerreviewedYesen
dc.publisherSpringeren
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.titleA Molecularly Imprinted Polymer Nanoparticle Based Surface Plasmon Resonance Sensor Platform for Antibiotic Detection in River Water and Milken
dc.typeArticleen

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