Synthesis, DNA interactions and cytotoxicity of novel chloroethylaminoanthraquinones

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dc.contributor.authorPaniwnyk, Zennia
dc.date.accessioned2017-02-15T10:54:50Z
dc.date.available2017-02-15T10:54:50Z
dc.date.issued2000
dc.description.abstractThe design of DNA directed nitrogen mustards has led to the development of compounds with increased specificity for DNA and enhanced cytotoxicity compared to similar untargeted mustards. By linking an intercalating anthraquinone chromophore to a nitrogen mustard function it was anticipated that such compounds would also have the potential to irreversibly inhibit the topoisomerase II (topo II) enzyme.en
dc.identifier.urihttp://hdl.handle.net/2086/13278
dc.language.isoenen
dc.publisherDe Montfort Universityen
dc.subject.ddc615.1en
dc.titleSynthesis, DNA interactions and cytotoxicity of novel chloroethylaminoanthraquinonesen
dc.typeThesis or dissertationen
dc.type.qualificationlevelDoctoralen
dc.type.qualificationnamePhDen

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