Synthesis, DNA interactions and cytotoxicity of novel chloroethylaminoanthraquinones
Date
2000
Authors
Advisors
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DOI
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Publisher
De Montfort University
Type
Thesis or dissertation
Peer reviewed
Abstract
The design of DNA directed nitrogen mustards has led to the development of compounds with increased specificity for DNA and enhanced cytotoxicity compared to similar untargeted mustards. By linking an intercalating anthraquinone chromophore to a nitrogen mustard function it was anticipated that such compounds would also have the potential to irreversibly inhibit the topoisomerase II (topo II) enzyme.