Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles

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dc.cclicenceCC-BY-NCen
dc.contributor.authorPoma, Alessandroen
dc.contributor.authorBrahmbhatt, Helien
dc.contributor.authorPendergraff, H. Men
dc.contributor.authorWatts, Jonathan Ken
dc.contributor.authorTurner, Nicholas W.en
dc.date.acceptance2014-11-20en
dc.date.accessioned2018-11-01T14:03:05Z
dc.date.available2018-11-01T14:03:05Z
dc.date.issued2015-01-21
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.en
dc.description.abstractA strategy to exploit aptamers as recognition elements of molecularly imprinted polymeric nanoparticles (AptaMIP NPs) is presented, via modification of the chemical structure of the DNA. It is demonstrated that the introduction of this modified “aptamer monomer” results in an increase of the affinity of the produced MIP NPs, without altering their physical properties such as size, shape, or dispersibility.en
dc.funderEPSRC (Engineering and Physical Sciences Research Council)en
dc.identifier.citationPoma, A., Brahmbhatt, H., Pendergraff, H.M., Watts, J.K., Turner, N.W. (2015) Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles. Advanced Materials, 27(4), pp.750–758.en
dc.identifier.doihttps://doi.org/10.1002/adma.201404235
dc.identifier.issn0935-9648
dc.identifier.urihttp://oro.open.ac.uk/41986/
dc.identifier.urihttp://hdl.handle.net/2086/16991
dc.language.isoenen
dc.peerreviewedYesen
dc.projectidEP/K015095/1en
dc.publisherWileyen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.subjectaptamersen
dc.subjectcocaineen
dc.subjectmolecular imprintingen
dc.subjectnanoparticlesen
dc.titleGeneration of novel hybrid aptamer-molecularly imprinted polymeric nanoparticlesen
dc.typeArticleen

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