Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles
Date
2015-01-21
Advisors
Journal Title
Journal ISSN
ISSN
0935-9648
Volume Title
Publisher
Wiley
Type
Article
Peer reviewed
Yes
Abstract
A strategy to exploit aptamers as recognition elements of molecularly imprinted polymeric nanoparticles (AptaMIP NPs) is presented, via modification of the chemical structure of the DNA. It is demonstrated that the introduction of this modified “aptamer monomer” results in an increase of the affinity of the produced MIP NPs, without altering their physical properties such as size, shape, or dispersibility.
Description
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.
Keywords
aptamers, cocaine, molecular imprinting, nanoparticles
Citation
Poma, A., Brahmbhatt, H., Pendergraff, H.M., Watts, J.K., Turner, N.W. (2015) Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles. Advanced Materials, 27(4), pp.750–758.