Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles

Abstract

A strategy to exploit aptamers as recognition elements of molecularly imprinted polymeric nanoparticles (AptaMIP NPs) is presented, via modification of the chemical structure of the DNA. It is demonstrated that the introduction of this modified “aptamer monomer” results in an increase of the affinity of the produced MIP NPs, without altering their physical properties such as size, shape, or dispersibility.

Description

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.

Keywords

aptamers, cocaine, molecular imprinting, nanoparticles

Citation

Poma, A., Brahmbhatt, H., Pendergraff, H.M., Watts, J.K., Turner, N.W. (2015) Generation of novel hybrid aptamer-molecularly imprinted polymeric nanoparticles. Advanced Materials, 27(4), pp.750–758.

Rights

Research Institute

Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)