Hyphenated mass spectrometry techniques for assessing medication adherence: advantages, challenges, clinical applications and future perspectives

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dc.cclicenceCC-BY-NDen
dc.contributor.authorTanna, Sangeeta
dc.contributor.authorOgwu, John
dc.contributor.authorLawson, Graham
dc.date.acceptance2019-11-19
dc.date.accessioned2020-02-03T14:16:15Z
dc.date.available2020-02-03T14:16:15Z
dc.date.issued2020-01-11
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.en
dc.description.abstractNonadherence to prescribed pharmacotherapy is an understated public health problem globally and is costing many patients their chance to return to good health and healthcare systems billions. Clinicians need an accurate assessment of adherence to medications to aid the clinical decision-making process in the event of poor patient progress and to maximize the patient health outcomes from the drug therapies prescribed. An overview of indirect and direct methods used to measure medication adherence is presented, highlighting the potential for accurate measuring of drugs in biological samples using hyphenated mass spectrometry techniques to provide healthcare professionals with a reliable evidence base for clinical decision making. In this review we summarise published applications of hyphenated mass spectrometry techniques for a diverse range of clinical areas demonstrating the rise in the use of such direct methods for assessing medication adherence. Although liquid chromatography-tandem mass spectrometry methods using plasma, serum and urine samples are the most popular, in recent years increased attention has been given to liquid chromatography high-resolution mass spectrometry methods and alternative biosample matrices including hair, saliva and blood microsamples. The advantages and challenges of using hyphenated mass spectrometry techniques to address this healthcare problem are also discussed alongside future perspectives.en
dc.funderNo external funderen
dc.identifier.citationTanna, S., Ogwu, J. and Lawson, G. (2020) Hyphenated mass spectrometry techniques for assessing medication adherence: advantages, challenges, clinical applications and future perspectives. Clinical Chemistry and Laboratory Medicine,en
dc.identifier.doihttps://doi.org/10.1515/cclm-2019-0820
dc.identifier.issn1437-4331
dc.identifier.urihttps://dora.dmu.ac.uk/handle/2086/19099
dc.language.isoenen
dc.peerreviewedYesen
dc.projectidN/Aen
dc.publisherDe Gruyteren
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.subjectBioanalysisen
dc.subjectHyphenated techniquesen
dc.subjectLiquid-chromatography-tandem mass spectrometryen
dc.subjectLiquid-chromatography-high resolution mass spectrometryen
dc.subjectMedication adherenceen
dc.titleHyphenated mass spectrometry techniques for assessing medication adherence: advantages, challenges, clinical applications and future perspectivesen
dc.typeArticleen

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