Influence of surface-imprinted nanoparticles on trypsin activity
Date
2014-03-20
Advisors
Journal Title
Journal ISSN
ISSN
2192-2659
Volume Title
Publisher
Wiley
Type
Article
Peer reviewed
Yes
Abstract
Here, the modulation of enzyme activity is presented by protein‐imprinted nanoparticles produced using a solid‐phase approach. Using trypsin as target, binding of the nanoparticles to the enzyme results in its inhibition or in stabilization, depending on the orientation of the immobilized enzyme used during imprinting.
Description
The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.
Keywords
enzyme inhibition, molecularly imprinted polymers, molecular recognition, nanoparticles, supramolecular chemistry
Citation
Guerreiro, A., Poma, A., Karim, K., Moczko, E., Takarada, J., de Vargas-Sansalvador, I., Turner, N.W., Piletska, E., de Magalhães, C.S., Glazova, N., Serkova, A., Omelianova, A., Piletsky, S.(2014) Influence of surface-imprinted nanoparticles on trypsin activity. Advanced Healthcare Materials, 3(9), pp.1426–1429.