Porous Inorganic Drug Delivery Systems—a Review

Date

2017-02-28

Advisors

Journal Title

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Volume Title

Publisher

Springer

Type

Article

Peer reviewed

Abstract

Innovative methods and materials have been developed to overcome limitations associated with current drug delivery systems. Significant developments have led to the use of a variety of materials (as excipients) such as inorganic and metallic structures, marking a transition from conventional polymers. Inorganic materials, especially those possessing significant porosity, are emerging as good candidates for the delivery of a range of drugs (antibiotics, anticancer and anti-inflammatories), providing several advantages in formulation and engineering (encapsulation of drug in amorphous form, controlled delivery and improved targeting). This review focuses on key selected developments in porous drug delivery systems. The review provides a short broad overview of porous polymeric materials for drug delivery before focusing on porous inorganic materials (e.g. Santa Barbara Amorphous (SBA) and Mobil Composition of Matter (MCM)) and their utilisation in drug dosage form development. Methods for their preparation and drug loading thereafter are detailed. Several examples of porous inorganic materials, drugs used and outcomes are discussed providing the reader with an understanding of advances in the field and realistic opportunities.

Description

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.

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Citation

Sayed, E. et al. (2017) Porous Inorganic Drug Delivery Systems—a Review. AAPS PharmSciTech, 18 (5), pp. 15071525

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Research Institute

Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)