Anticancer Potential of Flavones.

Date

2017-11-17

Advisors

Journal Title

Journal ISSN

ISSN

2504-3900

Volume Title

Publisher

MDPI

Type

Conference

Peer reviewed

Yes

Abstract

Many papers have been written on the anticancer properties of dietary flavonoids, and a range of potential mechanisms of action of flavonoids. However, most dietary flavonoids - notably polyphenolic flavonoids—have very poor ADME properties, and the levels necessary to stop growth of tumour cells cannot be sustained in a human body trough dietary intake alone. At present no flavonoid based drugs are clinically used in cancer therapy. Thus, whereas epidemiological and pre-clinical data seem to indicate a high potential for flavonoids, from the point of view of the pharmaceutical industry and drug developers, they are considered poor candidates. The flavones—which constitute a subgroup of the flavonoids—show some structural analogy with oestrogen and are known to interact with human oestrogen receptors, either as agonist or as antagonist. They are classed as phytoestrogens, and may play a role in cancer prevention through a mechanism of action possibly similar to that of the clinically used medication tamoxifen. Flavones are abundantly present in common fruits and vegetables, many of which have been associated with cancer prevention. Their phytoestrogen activity makes that they can assert their biological action at concentrations that are realistically achievable in the human systemic circulation.

Description

Abstract of presentation given at the 2nd International Conference on Natural Products for Cancer Prevention and Therapy (NPCPT-2017), 8-11 November 2017, Kayseri, Turkey. open access article

Keywords

flavones, phytoestrogens, apigenin

Citation

Arroo, R.R.J., Şöhretoğlu, D., Spandidos, D.A. and Androutsopoulos, V.P. (2017) Anticancer Potential of Flavones. Proceedings 2017, 1 (10), 975

Rights

Research Institute

Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)