Regulation of Amino Acid Metabolism in Hematological Malignancies: Advances from Transcriptomics and Metabolomics

Date

2022-12-12

Advisors

Journal Title

Journal ISSN

ISSN

2766-2276

Volume Title

Publisher

Type

Article

Peer reviewed

Yes

Abstract

Tumor cells use amino acids to rewire metabolic pathways to meet increased demands for energy, reducing equivalents, and cellular biosynthesis. Aside acting as building blocks for protein synthesis, amino acids also function as metabolic intermediates for ATP generation and redox homeostasis, as well as fueling biosynthetic pathways. Tumor-related metabolic changes infl uence every stage of the interaction between cells and their metabolites. Over the years, advancements in molecular methods such as transcriptomics and metabolomics have emerged to provide in-depth knowledge into the functions, interactions, and actions of molecules in cells of organisms. These technologies surfaced as methods that provide a more complete picture of disease pathophysiology, facilitating the elucidation of disease mechanisms and identify cation of potential biomarkers (metabolites) and targets (genes) respectively. Though Omics in cancer research have been explored in different concepts, however, employing these methods in amino acid metabolism in hematological cancers still requires attention. Therefore, this mini review discusses an up-to-date knowledge of principal regulators and their role in amino acid metabolism in hematological malignancies. In that perspective, we cover relevant fi ndings from transcriptomics and metabolomics, thereby constructing mechanistic insights associated with disease pathogenesis.

Description

open access article STER Internationalisation of Doctoral Schools Programme

Keywords

Amino acid metabolism, Gene expression, Metabolites, Transcriptomics, Metabolomics, Hematological malignancies

Citation

Bajia, D., Neba Ambe, GNN., Derwich, K. (2022) Regulation of Amino Acid Metabolism in Hematological Malignancies: Advances from Transcriptomics and Metabolomics. Journal of Biomedical Research and Environmental Science 3 (12), pp. 1478-1494

Rights

Research Institute

Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)