Stability of isocyanates sampled in fire smokes

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dc.cclicenceN/Aen
dc.contributor.authorBengtstrom, L.en
dc.contributor.authorSalden, Men
dc.contributor.authorStec, A.en
dc.date.acceptance2018-08-11en
dc.date.accessioned2018-08-14T13:29:46Z
dc.date.available2018-08-14T13:29:46Z
dc.date.issued2018-08-11
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.en
dc.description.abstractInhalation of airborne isocyanates is associated with acute asthma attacks and inflammation in the respiratory tract as well as cancer. These highly reactive compounds are used as monomers in various applications such as foams for insulation materials and upholstery furniture and are therefore commonly found in fire smoke from insulation materials, such as rigid polyisocyanurate (PIR) foams. Consequently, there is an increasing concern regarding the potential adverse health effects they may cause during this type of exposure. The aim of this study was to investigate the stability of generated isocyanates from aerobic pyrolysis of PIR after sampling in the derivatization solution as well as after sample preparation to establish the optimal storage conditions and rate of degradation. Both airborne and particle-bound isocyanates were collected, using dibutylamine as derivatization agent in a midget impinger and impregnated filter after the impinger. The rapid degradation of the generated isocyanates after sampling emphasizes the need for a prompt sample preparation and analysis, in particular for the collected mono-isocyanates, as the concentration decreased by 50% within 4–8 h.en
dc.funderN/Aen
dc.identifier.citationBengtström, L., Salden, M. and Stec, A. (2018) Stability of Isocyanates Sampled in Fire Smokes, Annals of Work Exposures and Health, 62 (9), pp. 1171-1175en
dc.identifier.doihttps://doi.org/10.1093/annweh/wxy072
dc.identifier.urihttp://hdl.handle.net/2086/16462
dc.language.isoenen
dc.peerreviewedYesen
dc.projectidN/Aen
dc.publisherOxford University Pressen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.subjectfireen
dc.subjectfire toxicityen
dc.subjectfoamen
dc.subjectHPLC-MS/MSen
dc.subjectisocyanatesen
dc.subjectpolyisocyanurateen
dc.titleStability of isocyanates sampled in fire smokesen
dc.typeArticleen

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