Montelukast photodegradation: Elucidation of Ф-order kinetics, determination of quantum yields and application to actinometry.

dc.cclicenceCC-BY-NCen
dc.contributor.authorMaafi, W.en
dc.contributor.authorMaafi, Mouniren
dc.date.acceptance2014-05-08en
dc.date.accessioned2018-11-02T11:31:51Z
dc.date.available2018-11-02T11:31:51Z
dc.date.issued2014-05-15
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.en
dc.description.abstractA recently developed F–order semi–emperical integrated rate–law for photoreversible AB(2F) photoreversible reactions has been successfully applied to investigate Montelukast sodium (Monte) photodegradation kinetics in ethanol. The model equations also served to propose a new stepwise kinetic elucidation method valid for any AB(2F) system and its application to the determination of Monte forward (ΦA→Blirr) and reverse (ΦB→Alirr ) quantum yields at various irradiation wavelengths. It has been found that ΦA→Blirr undergoes a 15–fold increase with wavelength between 220 and 360 nm, with the spectral section 250 – 360 nm representing Monte effective photodegradation causative range. The reverse quantum yield values were generally between 12 and 54 % lower than those recorded for ΦA→Blirr, with the trans–isomer (Monte) converts almost completely to its cis–counterpart at high irradiation wavelengths. Furthermore, the potential use of Monte as an actinometer has been investigated and an actinometric method was proposed. This study demonstrated the usefulness of Monte for monochromatic light actinometry for the dynamic range 258 – 380nm.en
dc.funderNAen
dc.identifier.citationMaafi, M. and Maafi, W. (2014) Montelukast photodegradation: Elucidation of Φ-order kinetics, determination of quantum yields and application to actinometry. International Journal of Pharmaceutics, 471 (1-2), pp. 544-552en
dc.identifier.doihttps://doi.org/10.1016/j.ijpharm.2014.05.016
dc.identifier.urihttp://hdl.handle.net/2086/17042
dc.language.isoenen
dc.peerreviewedYesen
dc.projectidNAen
dc.publisherElsevieren
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.subjectMontelukasten
dc.subjectphotodegradationen
dc.subjectspectrokineticsen
dc.subjectphotoisomerismen
dc.subjectactinometryen
dc.subjectquantum yielden
dc.titleMontelukast photodegradation: Elucidation of Ф-order kinetics, determination of quantum yields and application to actinometry.en
dc.typeArticleen

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