Novel syntheses of (Z)-alkene and alkane base-modified nucleosides.
dc.contributor.author | Lee, Sarah E. | en |
dc.contributor.author | Vyle, Joseph S. | en |
dc.contributor.author | Williams, David M. | en |
dc.contributor.author | Grasby, Jane A. | en |
dc.date.accessioned | 2013-10-15T09:51:41Z | |
dc.date.available | 2013-10-15T09:51:41Z | |
dc.date.issued | 2000-01 | |
dc.description.abstract | The syntheses of 5-(Z)-(3-aminoallyl)- and 5-(3-aminopropyl)-substituted 2′-deoxyuridine and 2′-deoxycytidine are reported. These compounds were derived from the corresponding 5-propargylamine derivative. [Hobbs, F. W. J. Org. Chem.1989, 52, 3420.] The catalyst we have employed for these reductions is a NiCl2/NaBH4 system, which we have found to be superior to the more conventional palladium-catalysts previously reported with similar compounds. | en |
dc.funder | N/A | en |
dc.identifier.citation | Lee, S.E. et al. (2000) Novel syntheses of (Z)-alkene and alkane base-modified nucleosides. Tetrahedron Letters, 2000, 41 (2), pp. 267-270. | en |
dc.identifier.doi | https://doi.org/10.1016/S0040-4039(99)02029-8 | |
dc.identifier.issn | 0040-4039 | |
dc.identifier.uri | http://hdl.handle.net/2086/9198 | |
dc.language.iso | en | en |
dc.projectid | N/A | en |
dc.publisher | Elsevier. | en |
dc.subject | Pyrimidines | en |
dc.subject | Alkenes | en |
dc.subject | Nucleosides | en |
dc.subject | Reduction | en |
dc.title | Novel syntheses of (Z)-alkene and alkane base-modified nucleosides. | en |
dc.type | Article | en |
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