Modelling of DNA Mismatch Repair with a reversible process calculus
| dc.cclicence | CC-BY-NC-ND | en |
| dc.contributor.author | Kuhn, Stefan | |
| dc.contributor.author | Ulidowski, Irek | |
| dc.date.acceptance | 2022-06-06 | |
| dc.date.accessioned | 2022-06-14T13:57:19Z | |
| dc.date.available | 2022-06-14T13:57:19Z | |
| dc.date.issued | 2022-06-10 | |
| dc.description | The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. | en |
| dc.description.abstract | We have demonstrated in previous work that the Calculus of Covalent Bonding (CCB) can be used to simulate higher-level biochemical processes. This is significant since CCB was originally devised to model lower level organic chemical reactions. In this paper we extend the use of the calculus to model an important gene repair pathway, namely DNA Mismatch Repair (MMR). This complex pathway involves four helper proteins and needs a distinction between the two chains in a DNA strand. In order to achieve this, we extend the calculus by allowing prefixing with collections of bonding sites. | en |
| dc.funder | No external funder | en |
| dc.identifier.citation | Kuhn, S. and Ulidowski, I. (2022) Modelling of DNA Mismatch Repair with a reversible process calculus. Theoretical Computer Science, Vol.295, pages 68-86 | en |
| dc.identifier.doi | https://doi.org/10.1016/j.tcs.2022.06.009 | |
| dc.identifier.issn | 0304-3975 | |
| dc.identifier.uri | https://hdl.handle.net/2086/21972 | |
| dc.language.iso | en | en |
| dc.peerreviewed | Yes | en |
| dc.publisher | Elsevier | en |
| dc.researchinstitute | Cyber Technology Institute (CTI) | en |
| dc.subject | Reversible computation | en |
| dc.subject | Calculus of Covalent Bonding | en |
| dc.subject | DNA Mismatch Repair | en |
| dc.title | Modelling of DNA Mismatch Repair with a reversible process calculus | en |
| dc.type | Article | en |