Modelling of DNA Mismatch Repair with a reversible process calculus

Date

2022-06-10

Advisors

Journal Title

Journal ISSN

ISSN

0304-3975

Volume Title

Publisher

Elsevier

Type

Article

Peer reviewed

Yes

Abstract

We have demonstrated in previous work that the Calculus of Covalent Bonding (CCB) can be used to simulate higher-level biochemical processes. This is significant since CCB was originally devised to model lower level organic chemical reactions. In this paper we extend the use of the calculus to model an important gene repair pathway, namely DNA Mismatch Repair (MMR). This complex pathway involves four helper proteins and needs a distinction between the two chains in a DNA strand. In order to achieve this, we extend the calculus by allowing prefixing with collections of bonding sites.

Description

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.

Keywords

Reversible computation, Calculus of Covalent Bonding, DNA Mismatch Repair

Citation

Kuhn, S. and Ulidowski, I. (2022) Modelling of DNA Mismatch Repair with a reversible process calculus. Theoretical Computer Science, Vol.295, pages 68-86

Rights

Research Institute

Cyber Technology Institute (CTI)