Mitochondrial physiology

dc.cclicenceCC-BYen
dc.contributor.authorGnaiger, Erich
dc.contributor.authorMoisoi, Nicoleta
dc.contributor.authorMitoEAGLE, Task Group
dc.date.acceptance2020-05-20
dc.date.accessioned2020-06-02T14:56:29Z
dc.date.available2020-06-02T14:56:29Z
dc.date.issued2020-05-20
dc.descriptionopen access journalen
dc.description.abstractAs the knowledge base and importance of mitochondrial physiology to evolution, health and disease expands, the necessity for harmonizing the terminology concerning mitochondrial respiratory states and rates has become increasingly apparent. The chemiosmotic theory establishes the mechanism of energy transformation and coupling in oxidative phosphorylation. The unifying concept of the protonmotive force provides the framework for developing a consistent theoretical foundation of mitochondrial physiology and bioenergetics. We follow the latest SI guidelines and those of the International Union of Pure and Applied Chemistry (IUPAC) on terminology in physical chemistry, extended by considerations of open systems and thermodynamics of irreversible processes. The concept-driven constructive terminology incorporates the meaning of each quantity and aligns concepts and symbols with the nomenclature of classical bioenergetics. We endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes. Uniform standards for evaluation of respiratory states and rates will ultimately contribute to reproducibility between laboratories and thus support the development of data repositories of mitochondrial respiratory function in species, tissues, and cells. Clarity of concept and consistency of nomenclature facilitate effective transdisciplinary communication, education, and ultimately further discovery.en
dc.funderNo external funderen
dc.funder.otherCOST Action CA15203en
dc.identifier.citationGnaiger, E., Moisoi, N., MitoEAGLE Task Group (2020) Mitochondrial physiology. Bioenergetics Communications, 2020.1.en
dc.identifier.doihttps://doi.org/10.26124/bec:2020-0001.v1
dc.identifier.urihttps://dora.dmu.ac.uk/handle/2086/19705
dc.language.isoenen
dc.projectidN/Aen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.subjectmitochondrial physiologyen
dc.titleMitochondrial physiologyen
dc.typeArticleen

Files

Original bundle
Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
BEC_2020.1_doi10.26124bec2020-0001.v1.pdf
Size:
2 MB
Format:
Adobe Portable Document Format
Description:
main article
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.2 KB
Format:
Item-specific license agreed upon to submission
Description: