Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular diseases—FLAVURS: a randomised controlled trial

Simple item page
dc.cclicenceCC-BY-NCen
dc.contributor.authorMacready, A.L.
dc.contributor.authorGeorge, T.W.
dc.contributor.authorChong, M.F.
dc.contributor.authorAlimbetov, Dauren
dc.contributor.authorJin, Yannan
dc.contributor.authorVidal, Alberto
dc.contributor.authorSpencer, J.P.E.
dc.contributor.authorKennedy, O.B.
dc.contributor.authorTuohy, K.M.
dc.contributor.authorMinihane, A.
dc.contributor.authorGordon, M.H.
dc.contributor.authorLovegrove, J.A.
dc.date.acceptance2013-12-20
dc.date.accessioned2019-06-12T14:14:20Z
dc.date.available2019-06-12T14:14:20Z
dc.date.issued2014-01-22
dc.descriptionThe Publisher's final version can be found by following the DOI link.en
dc.description.abstractackground: Observed associations between increased fruit and vegetable (F&V) consumption, particularly those F&Vs that are rich in flavonoids, and vascular health improvements require confirmation in adequately powered randomized controlled trials. Objective: This study was designed to measure the dose-response relation between high-flavonoid (HF), low-flavonoid (LF), and habitual F&V intakes and vascular function and other cardiovascular disease (CVD) risk indicators. Design: A single-blind, dose-dependent, parallel randomized controlled dietary intervention study was conducted. Male and female low-F&V consumers who had a ≥1.5-fold increased risk of CVD (n = 174) were randomly assigned to receive an HF F&V, an LF F&V, or a habitual diet, with HF and LF F&V amounts sequentially increasing by 2, 4, and 6 (+2, +4, and +6) portions/d every 6 wk over habitual intakes. Microvascular reactivity (laser Doppler imaging with iontophoresis), arterial stiffness [pulse wave velocity, pulse wave analysis (PWA)], 24-h ambulatory blood pressure, and biomarkers of nitric oxide (NO), vascular function, and inflammation were determined at baseline and at 6, 12, and 18 wk. Results: In men, the HF F&V diet increased endothelium-dependent microvascular reactivity (P = 0.017) with +2 portions/d (at 6 wk) and reduced C-reactive protein (P = 0.001), E-selectin (P = 0.0005), and vascular cell adhesion molecule (P = 0.0468) with +4 portions/d (at 12 wk). HF F&Vs increased plasma NO (P = 0.0243) with +4 portions/d (at 12 wk) in the group as a whole. An increase in F&Vs, regardless of flavonoid content in the groups as a whole, mitigated increases in vascular stiffness measured by PWA (P = 0.0065) and reductions in NO (P = 0.0299) in the control group. Conclusion: These data support recommendations to increase F&V intake to ≥6 portions daily, with additional benefit from F&Vs that are rich in flavonoids, particularly in men with an increased risk of CVD. This trial was registered at www.controlled-trials.com as ISRCTN47748735.en
dc.exception.ref2021codes254aen
dc.funderOther external funder (please detail below)en
dc.funder.otherFood Standards Agency UKen
dc.identifier.citationMacready, A.L., George, T.W., Chong, M.F., Alimbetov, D., Jin, Y., Vidal, A., Spencer, J.P.E., Kennedy, O.B., Tuohy, K.M., Minihane, A., Gordon, M.H., Lovegrove, J.A. (2014) Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular diseases—FLAVURS: a randomised controlled trial. American Journal of Clinical Nutrition, 99, pp.479-89.en
dc.identifier.doihttps://doi.org/10.3945/ajcn.113.074237
dc.identifier.urihttp://nrl.northumbria.ac.uk/id/eprint/17999
dc.identifier.urihttps://www.dora.dmu.ac.uk/handle/2086/18040
dc.language.isoenen
dc.peerreviewedYesen
dc.publisherOxford University Pressen
dc.researchinstituteInstitute for Allied Health Sciences Researchen
dc.titleFlavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular diseases—FLAVURS: a randomised controlled trialen
dc.typeArticleen

Files

License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

School of Allied Health Sciences