LC-HRMS analysis of 133 patient micro-volume blood samples to allow clinical assessment of medication adherence

Date

2017-01-25

Advisors

Journal Title

Journal ISSN

ISSN

DOI

Volume Title

Publisher

The Association for Mass Spectrometry: Applications to the Clinical Lab

Type

Conference

Peer reviewed

Yes

Abstract

133 DBS card/VAMS micro-volume blood samples were analysed by LC-HRMS to determine if therapeutic levels of the prescribed cardiovascular (CVD) drugs were present. This research focussed on the top 11 UK prescribed CVD drugs. Calibration samples, prepared from spiked human whole blood, were extracted and analysed by LC-HRMS. This method was validated and applied to volunteer and patient samples. The system successfully identified the prescribed drugs in volunteer’s samples who were known to be adherent. Non-detection of a prescribed drug indicated non-adherence to prescription: a situation identified for 12% of the volunteers and 36% of the patients.

Description

Keywords

dried blood spots, adherence, LC-HRMS, micro-sampling

Citation

Tanna, S., Alalaqi, A., Bernieh, D. and Lawson, G. (2017) LC-HRMS analysis of 133 patient micro-volume blood samples to allow clinical assessment of medication adherence. Mass Spectrometry: Applications to the Clinical Lab (MSACL) 2017. Palm Springs, USA. 22-26 January 2017

Rights

Research Institute

Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)