Mechanochemically induced disordered structures of vincamine: The different mediation of two cross-linked polymers
| dc.cclicence | CC-BY-NC-ND | en |
| dc.contributor.author | Hasa, Dritan | en |
| dc.contributor.author | Perissutti, Beatrice | en |
| dc.contributor.author | Chierotti, Michele R. | en |
| dc.contributor.author | Gobetto, Roberto | en |
| dc.contributor.author | Grabnar, Iztok | en |
| dc.contributor.author | Bonifacio, Alois | en |
| dc.contributor.author | Dall’Acqua, Stefano | en |
| dc.contributor.author | Invernizzi, Sergio | en |
| dc.contributor.author | Voinovich, Dario | en |
| dc.date.accessioned | 2017-04-27T09:29:47Z | |
| dc.date.available | 2017-04-27T09:29:47Z | |
| dc.date.issued | 2012-06-18 | |
| dc.description | The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. | en |
| dc.description.abstract | The aims of this research were to prepare highly bioavailable binary cogrounds (vincamine–AcDiSol® or PVP-Cl) by means of a mechanochemical process and to study the mediation of each polymer in the induction of physical transformations of the drug. From a set of fifteen cogrounds for each crosslinked polymer, two samples were selected in each group on the basis of the AUC of in vitro dissolution profiles with the help of a statistical comparison. The chosen samples were analysed by means of TEM, XRPD, Raman-spectroscopy/imaging, SSNMR, also including the study of 1H spin–lattice relaxation times. The research encompassed in vivo oral absorption studies in rats, pharmacokinetic analysis and physical stability studies during 1 year. An intimate drug–polymer mixing was found in the coground samples with domain average dimensions smaller than 100A˚ ; this reflected in a remarkable enhancement of the in vitro and in vivo bioavailability. Different disordered states were detected in the coground samples as a function of cogrinding time and the type and amount of polymer used. Though both crosslinked polymers produced a remarkable enhancement of the oral bioavailability, coground systems based on AcDiSol® are preferable in terms of pharmacokinetic performance and physical stability. | en |
| dc.funder | N/A | en |
| dc.identifier.citation | Hasa, D. et al. (2012) Mechanochemically induced disordered structures of vincamine: The different mediation of two cross-linked polymers. International Journal of Pharmaceutics, 436 (1-2), pp. 41-57 | en |
| dc.identifier.doi | https://doi.org/10.1016/j.ijpharm.2012.06.024 | |
| dc.identifier.uri | http://hdl.handle.net/2086/14112 | |
| dc.language.iso | en | en |
| dc.peerreviewed | Yes | en |
| dc.projectid | N/A | en |
| dc.publisher | Elsevier | en |
| dc.researchinstitute | Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI) | en |
| dc.title | Mechanochemically induced disordered structures of vincamine: The different mediation of two cross-linked polymers | en |
| dc.type | Article | en |