BOLD fMRI complexity predicts changes in brain processes, interactions and patterns, in health and disease

The human brain is the most complex information processing system that exists in nature. Its information processing functionality exists at multiple levels of interactions which can be influenced by electrical, chemical and physical components governed by thresholds and saturation phenomena [1]. When these thresholds are exceeded, saturation is reached, giving rise to nonlinear behaviour [22]. The human brain like most dynamic systems in nature typically exhibit chaotic and complex behaviours with nonlinear dynamic properties [3].