Can H2-receptor upregulation and raised histamine explain an anaphylactoid reaction on cessation of ranitidine in a 19 year old female?

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dc.cclicenceCC-BY-NCen
dc.contributor.authorAllen, Susanen
dc.contributor.authorDixon, C. J.en
dc.contributor.authorChazot P Len
dc.date.acceptance2018-02-27en
dc.date.accessioned2018-03-28T13:21:16Z
dc.date.available2018-03-28T13:21:16Z
dc.date.issued2018-04-18
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.en
dc.description.abstractThe anaphylactoid reaction described follows cessation of ranitidine in a 19 year old female with the disease cluster: mast cell activation syndrome, hypermobile Ehlers-Danlos syndrome and postural tachycardia syndrome. Anaphylaxis can give wide-ranging symptoms, from rhinorrhea and urticaria to tachycardia and system-wide, life-threatening, anaphylactic shock. Individuals with a disorder of mast cell activation can experience many such symptoms. H2 receptor antagonists, such as ranitidine, are commonly prescribed in this population. A mechanism for the reaction is proposed in the context of ranitidine, as an inverse agonist, causing upregulation of H2 histamine receptors and raised histamine levels due to enzyme induction. This effect, following extended and/or high antihistamine dosing, may have implications for other individuals with a disorder of mast cell activation, such as mastocytosis or mast cell activation syndrome. There are potential policy and patient guidance implications for primary and secondary care with respect to cessation of H2 antagonists.en
dc.funderN/Aen
dc.identifier.citationAllen, S.J., Chazot, P.L. and Dixon, C.J. (2018) Can H2-receptor upregulation and raised histamine explain an anaphylactoid reaction on cessation of ranitidine in a 19 year old female? British Journal of Clinical Pharmacology, (in press)en
dc.identifier.doihttps://doi.org/10.1111/bcp.13578
dc.identifier.issn0306-5251
dc.identifier.urihttp://hdl.handle.net/2086/15659
dc.language.isoenen
dc.peerreviewedYesen
dc.projectidN/Aen
dc.publisherWiley
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.subjectRanitidineen
dc.subjectMast cell activationen
dc.subjectH2 receptorsen
dc.subjectAnaphylactoid reactionen
dc.titleCan H2-receptor upregulation and raised histamine explain an anaphylactoid reaction on cessation of ranitidine in a 19 year old female?en
dc.typeArticleen

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