Robust Nuclear Magnetic Resonance (NMR) Spectroscopy Method for the Identification and Quantification of Phthalates in Fragments of Polyvinyl Chloride (PVC) Toys

Date

2022-12-10

Advisors

Journal Title

Journal ISSN

ISSN

1532-236X

Volume Title

Publisher

Taylor and Francis

Type

Article

Peer reviewed

Yes

Abstract

An efficient nuclear magnetic resonance (NMR)-based method was developed to detect and quantify the presence of phthalates in plastic fragments obtained from a children’s toy and cosmetic product containers. Bis-2-ethyl hexyl phthalate (BEHP) was present at a concentration of 8.5% w/w in the plastic toy residue. This indicates levels of phthalates above the permitted threshold (e.g., <0.1% w/w) imposed by EU and USA regulations restricting the use of plasticizers in plastic toys for children aged 0 to 3 years. An added value of this method is that the tetramethylsilane (TMS) internal standard present at a concentration of 2.2 mmol/L in commercially available CDCl3 solvents may be conveniently used for the quantitative nuclear magnetic resonance (qNMR) analysis. The protocol described here is highly reproducible and may be easily applied to large scale investigations of plasticizers content into polyvinyl chloride (PVC) polymers.

Description

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.

Keywords

Citation

Waheed, H., Zakirhussein, A., Ruparelia, K. and Brucoli, F. (2022) Robust Nuclear Magnetic Resonance (NMR) Spectroscopy Method for the Identification and Quantification of Phthalates in Fragments of Polyvinyl Chloride (PVC) Toys. Analytical Letters,

Rights

Research Institute

Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)