Dual Rotation Centrifugal Electrospinning: A Novel Approach to Engineer Multi-Directional and Layered Fiber Composite Matrices

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dc.cclicenceCC-BY-NCen
dc.contributor.authorWang, Lien
dc.contributor.authorWang, Baolinen
dc.contributor.authorAhmad, Z.en
dc.contributor.authorLi, Jing-Songen
dc.contributor.authorChang, Ming-Weien
dc.date.acceptance2018-09-26en
dc.date.accessioned2018-09-28T09:01:57Z
dc.date.available2018-09-28T09:01:57Z
dc.date.issued2018-10-19
dc.description.abstractIn this study, a dual rotation centrifugal electrospinning system (DRCES) is designed, developed and used to prepare medicated fabrics. Through simultaneous rotation of both spinneret and collector; multi-directional blended fiber matrices (PVP and TPU) were deposited directly on the rotating collector. To detail the process, key stages of the centrifugal electrospinning process are elaborated, and the influence of gas infusion and collector rotation speed on resulting fiber morphologies were explored. Multi-directional fibrous structures show in vitro biocompatibility (fibroblast). Regulation of drug release rate was achieved using polymer composition and filament alignment. This study demonstrates a rapid fabrication method (~ 50 g/h) to engineer layered fibrous structures using DRCES; which provides a foundation for preparing complex drug matrices (single and multi–directional) for tailored active component release.en
dc.funderN/Aen
dc.identifier.citationWang, Li. et al. (2018) Dual Rotation Centrifugal Electrospinning: A Novel Approach to Engineer Multi-Directional and Layered Fiber Composite Matrices. Drug Delivery and Translational Research, 9 (1), pp. 204-214en
dc.identifier.doihttps://doi.org/10.1007/s13346-018-00594-y
dc.identifier.urihttp://hdl.handle.net/2086/16651
dc.language.isoenen
dc.peerreviewedYesen
dc.projectidN/Aen
dc.publisherSpringeren
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.subjectcentrifugal electrospinningen
dc.subjectdual rotationen
dc.subjectlayersen
dc.subjectcomposite fiberen
dc.subjectmulti-directionalen
dc.titleDual Rotation Centrifugal Electrospinning: A Novel Approach to Engineer Multi-Directional and Layered Fiber Composite Matricesen
dc.typeArticleen

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