Prevalence of mutations within the quinolone resistance-determining region of gyrA, gyrB, parC, and parE and association with antibiotic resistance in quinolone-resistant Salmonella enterica.

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dc.contributor.authorGray, Douglas T.
dc.contributor.authorEaves, D. J.
dc.contributor.authorRandall, L.
dc.contributor.authorBuckley, A.
dc.contributor.authorWoodward, M. J.
dc.contributor.authorWhite, A. P.
dc.contributor.authorPiddock, L. J.
dc.date.accessioned2011-03-07T10:21:33Z
dc.date.available2011-03-07T10:21:33Z
dc.date.issued2004-10
dc.description.abstractSalmonella enterica isolates (n = 182) were examined for mutations in the quinolone resistance-determining region of gyrA, gyrB, parC, and parE. The frequency, location, and type of GyrA substitution varied with the serovar. Mutations were found in parC that encoded Thr57-Ser, Thr66-Ile, and Ser80-Arg substitutions. Mutations in the gyrB quinolone resistance-determining region were located at codon Tyr420-Cys or Arg437-Leu. Novel mutations were also found in parE encoding Glu453-Gly, His461-Tyr, Ala498-Thr, Val512-Gly, and Ser518-Cys. Although it is counterintuitive, isolates with a mutation in both gyrA and parC were more susceptible to ciprofloxacin than were isolates with a mutation in gyrA alone.en
dc.identifier.citationEaves, D.J., Randall, L., Gray, D.T., Buckley, A., Woodward, M.J., White, A.P., Piddock, L.J., (2004) Prevalence of mutations within the quinolone resistance-determining region of gyrA, gyrB, parC, and parE and association with antibiotic resistance in quinolone-resistant Salmonella enterica. Antimicrobial Agents and Chemotherapy, 48 (10) pp.4012-5en
dc.identifier.doihttps://doi.org/10.1128/AAC.48.10.4012-4015.2004
dc.identifier.issn1098-6596
dc.identifier.issn0066-4804
dc.identifier.urihttp://hdl.handle.net/2086/4676
dc.language.isoenen
dc.peerreviewedYesen
dc.publisherAmerican Society of Microbiologyen
dc.researchgroupBiomedical and Environmental Health
dc.researchgroupReproduction Research Group
dc.researchinstituteCentre for Reproduction Research (CRR)en
dc.titlePrevalence of mutations within the quinolone resistance-determining region of gyrA, gyrB, parC, and parE and association with antibiotic resistance in quinolone-resistant Salmonella enterica.en
dc.typeArticleen

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