The universal soldier: enzymatic and non-enzymatic antioxidant functions of serum albumin.

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dc.cclicenceCC-BY-NCen
dc.contributor.authorBelinskaia, D. A.
dc.contributor.authorVoronina, P.A.
dc.contributor.authorShmurak, V. I.
dc.contributor.authorVovk, M. A.
dc.contributor.authorBatalova, A.A.
dc.contributor.authorJenkins, R. O.
dc.contributor.authorGoncharov, N. V.
dc.date.acceptance2020-10-07
dc.date.accessioned2020-11-18T11:02:44Z
dc.date.available2020-11-18T11:02:44Z
dc.date.issued2020-10-09
dc.descriptionopen access articleen
dc.description.abstractAs a carrier of many biologically active compounds, blood is exposed to oxidants to a greater extent than the intracellular environment. Serum albumin plays a key role in antioxidant defence under both normal and oxidative stress conditions. This review evaluates data published in the literature and from our own research on the mechanisms of the enzymatic and non‐enzymatic activities of albumin that determine its participation in redox modulation of plasma and intercellular fluid. For the first time, the results of numerous clinical, biochemical, spectroscopic and computational experiments devoted to the study of allosteric modulation of the functional properties of the protein associated with its participation in antioxidant defence are analysed. It has been concluded that it is fundamentally possible to regulate the antioxidant properties of albumin with various ligands, and the binding and/or enzymatic features of the protein by changing its redox status. The perspectives for using the antioxidant properties of albumin in practice are discussed.en
dc.funderNo external funderen
dc.identifier.citationBelinskaia, D.A., Voronina, P.A., Shmurak, V.I., Vovk, M.A., Batalova, A.A., Jenkins, R.O., and Goncharov, N.V. (2020) The universal soldier: enzymatic and non-enzymatic antioxidant functions of serum albumin. Antioxidants,9(10), pp. 966.en
dc.identifier.doihttps://doi.org/10.3390/antiox9100966
dc.identifier.issn2076-3921
dc.identifier.urihttps://dora.dmu.ac.uk/handle/2086/20472
dc.language.isoenen
dc.peerreviewedYesen
dc.publisherMDPIen
dc.researchinstituteInstitute for Allied Health Sciences Researchen
dc.subjectalbuminen
dc.subjectantioxidant enzymesen
dc.subjectnon‐enzymatic antioxidant moleculesen
dc.subjectallosteric modulationen
dc.titleThe universal soldier: enzymatic and non-enzymatic antioxidant functions of serum albumin.en
dc.typeArticleen

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