Metabotropic glutamate receptor-mediated currents at the climbing fiber to Purkinje cell synapse

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dc.contributor.authorAndjus, P. R.en
dc.contributor.authorBajic, A.en
dc.contributor.authorZhu, Lanen
dc.contributor.authorSchachner, M.en
dc.contributor.authorStrata, Piergiorgioen
dc.date.accessioned2015-04-29T10:59:05Z
dc.date.available2015-04-29T10:59:05Z
dc.date.issued2005-11-28
dc.description.abstractDifferent forms of synaptic plasticity in the cerebellum expressed at the synapses onto Purkinje cells (PCs) are mediated by membrane metabotropic glutamate receptors (mGluRs). There are three main mGluR groups with a total of 8 subtypes. Although mGluRs are also found at the climbing fiber (CF) to PC synapses, the distribution and biological activity of their types is not well-known. Using whole cell patch-clamp recordings from PCs in rat cerebellar slices with inhibitors of ionotropic receptors and glutamate uptake blockers we demonstrate a complex pharmacology of currents obtained by CF stimulation. The mGluR1 specific antagonist CPCCOEt in a group of cells suppressed this response, but in a similar number of other cells it induced a potentiating effect. It was found that a switch between these two biopharmaceutical effects might occur with age.en
dc.funderMIURen
dc.funderItalian Ministry of Healthen
dc.funderESF-COST STSMen
dc.funderMinistry of Science and Environmental Protectionen
dc.identifier.citationAndjus, P. R et al. (2005) Metabotropic glutamate receptor-mediated currents at the climbing fiber to Purkinje cell synapse. Journal of chemical information and modelling, 45 (6), pp. 1536-1538en
dc.identifier.doihttps://doi.org/10.1021/ci050161s
dc.identifier.issn1549-9596
dc.identifier.urihttp://hdl.handle.net/2086/10920
dc.language.isoenen
dc.peerreviewedYesen
dc.projectidResearch supporten
dc.publisherACSen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.subjectcerebellumen
dc.subjectPurkinje cellen
dc.subjectmetabotropic glutamate receptoren
dc.subjectwhole cell patch recordingen
dc.subjectpharmacologyen
dc.titleMetabotropic glutamate receptor-mediated currents at the climbing fiber to Purkinje cell synapseen
dc.typeArticleen

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