Quantitative LC-HRMS analysis of dried blood spots to assess adherence to cardiovascular pharmacotherapy

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dc.cclicenceN/Aen
dc.contributor.authorLawson, Grahamen
dc.contributor.authorBernieh, Dennisen
dc.contributor.authorTanna, Sangeetaen
dc.date.acceptance2017-01-25en
dc.date.accessioned2017-03-28T09:50:07Z
dc.date.available2017-03-28T09:50:07Z
dc.date.issued2017-01-25
dc.description.abstractThe analysis of dried blood spot samples (DBS) by liquid chromatography – high resolution mass spectrometry (LC-HRMS) for assessing adherence to candidate cardiovascular therapeutic drugs was investigated. To evaluate the method 8 mm discs were punched from each DBS and extracted followed by subjecting to LC-HRMS analysis. Trials using the top 11 UK prescribed cardiovascular drugs are reported demonstrating the ability of the system to detect the target analytes during the 24 hour repeat prescription cycle. The system responded successfully to challenges by samples from volunteers of known adherence or receiving no medication. Examples of non-adherence to different medications were identified.en
dc.explorer.multimediaNoen
dc.funderN/Aen
dc.identifier.citationLawson, G., Bernieh, D. and Tanna S (2017) Quantitative LC-HRMS analysis of dried blood spots to assess adherence to cardiovascular pharmacotherapy. Mass Spectrometry: Applications to the Clinical Lab (MSACL) 2017. Palm Springs, USA. 22-26 January 2017en
dc.identifier.urihttp://hdl.handle.net/2086/13901
dc.language.isoenen
dc.peerreviewedYesen
dc.projectidN/Aen
dc.publisherThe Association for Mass Spectrometry: Applications to the Clinical Laben
dc.researchgroupPharmacy Practiceen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.subjectdried blood spotsen
dc.subjectquantitative analysisen
dc.subjectLC-HRMSen
dc.subjectAdherenceen
dc.titleQuantitative LC-HRMS analysis of dried blood spots to assess adherence to cardiovascular pharmacotherapyen
dc.typeConferenceen

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