Recent advances in chemistry, therapeutic properties and sources of polydatin

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dc.cclicenceCC-BY-NCen
dc.contributor.authorArroo, R. R. J.en
dc.contributor.authorSohretoglu, D.en
dc.contributor.authorYuzbasioglu, B.M.en
dc.contributor.authorKuruuzum-Uz, A.en
dc.date.acceptance2018-05-02en
dc.date.accessioned2018-06-06T10:53:26Z
dc.date.available2018-06-06T10:53:26Z
dc.date.issued2018-05-10
dc.descriptionJoint review by Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy and De Montfort University, Leicester School of Pharmacy.en
dc.description.abstractPolydatin (PLD), the 3-O-β-glucopyranoside of the well-known stilbenoid compound resveratrol, is a major compound of Fallopia japonica (Houtt.) R. Decr. (Japanese knotweed), which is widely used in traditional Chinese medicine to treat infection, inflammatory diseases and circulatory problems. It has shown a wide range of biological activities including anti-inflammatory, anti-oxidant, anti-cancer, neuroprotective, hepatoprotective, nephroprotective and immunostimulatory effects. Although resveratrol has similar beneficial effects, its low bioavailability has remained a problem. Glycosylation increases solubility of resveratrol in an aqueous environment, thus improving its bioavailability. This has led to a growing interest in PLD. Promising results obtained from bioactivity studies have boosted an intense research on this compound. The aim of this review is to give a comprehensive overview of the botanical sources, pharmacology, biosynthesis, biotechnological production, and bioactivities of PLD, and to discuss clinical studies on this compound.en
dc.fundern/aen
dc.identifier.citationŞöhretoğlu, D., Yüzbaşıoğlu, Baran M., Arroo, R., Kuruüzüm-Uz, A. (2018) Recent advances in chemistry, therapeutic properties and sources of polydatin. Phytochemistry Reviews, pp.1-33en
dc.identifier.doihttps://doi.org/10.1007/s11101-018-9574-0
dc.identifier.issn1568-7767
dc.identifier.issn1572-980X
dc.identifier.urihttp://hdl.handle.net/2086/16253
dc.language.isoenen
dc.projectidn/aen
dc.publisherSpringeren
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.subjectPolydatinen
dc.subjectPiceiden
dc.subjectstilbeneen
dc.subjectResveratrolen
dc.subjecttrans-resveratrol 3-O-glucosideen
dc.titleRecent advances in chemistry, therapeutic properties and sources of polydatinen
dc.typeArticleen

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