Recent advances in chemistry, therapeutic properties and sources of polydatin

Date

2018-05-10

Advisors

Journal Title

Journal ISSN

ISSN

1568-7767
1572-980X

Volume Title

Publisher

Springer

Type

Article

Peer reviewed

Abstract

Polydatin (PLD), the 3-O-β-glucopyranoside of the well-known stilbenoid compound resveratrol, is a major compound of Fallopia japonica (Houtt.) R. Decr. (Japanese knotweed), which is widely used in traditional Chinese medicine to treat infection, inflammatory diseases and circulatory problems. It has shown a wide range of biological activities including anti-inflammatory, anti-oxidant, anti-cancer, neuroprotective, hepatoprotective, nephroprotective and immunostimulatory effects. Although resveratrol has similar beneficial effects, its low bioavailability has remained a problem. Glycosylation increases solubility of resveratrol in an aqueous environment, thus improving its bioavailability. This has led to a growing interest in PLD. Promising results obtained from bioactivity studies have boosted an intense research on this compound. The aim of this review is to give a comprehensive overview of the botanical sources, pharmacology, biosynthesis, biotechnological production, and bioactivities of PLD, and to discuss clinical studies on this compound.

Description

Joint review by Hacettepe University, Faculty of Pharmacy, Department of Pharmacognosy and De Montfort University, Leicester School of Pharmacy.

Keywords

Polydatin, Piceid, stilbene, Resveratrol, trans-resveratrol 3-O-glucoside

Citation

Şöhretoğlu, D., Yüzbaşıoğlu, Baran M., Arroo, R., Kuruüzüm-Uz, A. (2018) Recent advances in chemistry, therapeutic properties and sources of polydatin. Phytochemistry Reviews, pp.1-33

Rights

Research Institute

Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)