A multi-faceted approach to determining the efficacy of metal and metal oxide nanoparticles against bacterial biofilms

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dc.cclicenceN/Aen
dc.contributor.authorTejpal, Jyotien
dc.contributor.authorCross, R. B. M.en
dc.contributor.authorOwen, Lucyen
dc.contributor.authorPaul, Shashien
dc.contributor.authorJenkins, R. O.en
dc.contributor.authorArmitage, Daviden
dc.contributor.authorLaird, Katieen
dc.date.acceptance2018-07-30en
dc.date.accessioned2018-08-06T14:01:20Z
dc.date.available2018-08-06T14:01:20Z
dc.date.issued2018-10-01
dc.description.abstractAntibacterial efficacy of nanoscale silver, copper (II) oxide and zinc oxide were assessed against Pseudomonas aeruginosa and Staphylococcus aureus biofilms in solution and on surfaces. Using a Center for Disease Control biofilm reactor, minimum biofilm reduction concentrations, the coefficient of determination (R2) and log(10) reductions were determined. Atomic absorption spectroscopy, scanning electron microscopy and confocal laser scanning microscopy were used to assess the disruption of the biofilms. The efficacy of thin films of zinc oxide and silver deposited via magnetron sputtering and thermal evaporation respectively was also assessed. Minimum biofilm reduction concentrations of zinc oxide or silver nanoparticles were 256 or 50 µg/ml for P. aeruginosa and 16 or50 µg/ml for S. aureus respectively. When tested in combination the nanoparticles concentrations were at least halved resulting in significant (p ≤0.05) biofilm reductions of 3.77 log(10) - 3.91 log(10). Biofilm growth on thin films resulted in reductions of up to 1.82 log(10). The results suggest that nanoparticle suspensions and thin films of zinc oxide and may have potential as antimicrobial treatments for hard to eliminate biofilms in a clinical environment.en
dc.exception.ref2021codes253cen
dc.funderN/Aen
dc.identifier.citationTejpal,J., Cross, R., Owen, L., Paul, S., Jenkins,R., Armitage, D., and Laird, K. (2018) A multi-faceted approach to determining the efficacy of metal and metal oxide nanoparticles against bacterial biofilms. Journal of Bionanoscience, 12 (5), pp. 705-714en
dc.identifier.doihttps://doi.org/10.1166/jbns.2018.1568
dc.identifier.urihttp://hdl.handle.net/2086/16433
dc.peerreviewedYesen
dc.projectidN/Aen
dc.publisherJournal of Bionanoscienceen
dc.researchgroupInfectious Disease Research Groupen
dc.researchinstituteInstitute of Engineering Sciences (IES)en
dc.researchinstituteInstitute for Allied Health Sciences Researchen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.titleA multi-faceted approach to determining the efficacy of metal and metal oxide nanoparticles against bacterial biofilmsen
dc.typeArticleen

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