Prenatal stress exposure is associated with increased dyspnea perception in adulthood

dc.cclicenceCC-BY-NC-NDen
dc.contributor.authorvon Leupoldt, Aen
dc.contributor.authorMangelschots, E.en
dc.contributor.authorNiederstrasser, Nils Georgen
dc.contributor.authorBraeken, M.en
dc.contributor.authorBilliet, T.en
dc.contributor.authorVan den Bergh, B.en
dc.date.acceptance2017-05-20en
dc.date.accessioned2018-05-15T10:42:54Z
dc.date.available2018-05-15T10:42:54Z
dc.date.issued2017-08-17
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.en
dc.description.abstractDyspnoea is the aversive cardinal symptom in various prevalent conditions such as respiratory, cardiovascular and neuromuscular diseases and is associated with great individual and socioeconomic burden [1]. Over the past years, several physiological and also psychological factors have been demonstrated to affect the perception of dyspnoea [1, 2]. For example, high levels of anxiety in adulthood were associated with increased dyspnoea perception in patients with asthma or chronic obstructive pulmonary disease (COPD), but also in healthy controls [2]. Moreover, adverse, separation-related experiences in childhood were linked to the subsequent development of increased anxiety and dyspnoea [3]. However, the effects of adverse experiences in early, prenatal life on dyspnoea perception remain widely unknown, although prenatal exposure to maternal stress and anxiety has convincingly been related to the development of other health and behavioural problems later in life, including impairments of the respiratory control system and high anxiety levels [4–9]. Therefore, this study investigated the relationship between prenatal exposure to maternal stress and the perception of dyspnoea in adulthood 28 years later.en
dc.exception.ref2021codes254aen
dc.funderEuropean Commission Seventh Framework Programmeen
dc.funderinfrastructure grant from the Herculesstichting, Belgiumen
dc.funder“Asthenes” long-term structural funding Methusalem granten
dc.identifier.citationVon Leupoldt, A., Mangelschots, E., Niederstrasser, N.G., Braeken, M., Billiet, T. and Van den Bergh, B.R. (2017) Prenatal stress exposure is associated with increased dyspnoea perception in adulthood. European Respiratory Journal, 50(2), pp.1700642.en
dc.identifier.doihttps://doi.org/10.1183/13993003.00642-2017
dc.identifier.urihttp://hdl.handle.net/2086/16171
dc.language.isoenen
dc.peerreviewedYesen
dc.projectidFP7–HEALTH.2011.2.2.2-2 BRAINAGE, Grant agreement no: 279281en
dc.projectidAKUL/13/07en
dc.projectid# METH/15/011en
dc.researchinstituteInstitute for Psychological Scienceen
dc.titlePrenatal stress exposure is associated with increased dyspnea perception in adulthooden
dc.typeArticleen

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