Sex differences in the effect of fish-oil supplementation on the adaptive response to resistance exercise training in older people: A randomized controlled trial

Simple item page
dc.cclicenceCC-BYen
dc.contributor.authorDa Boit, Mariasoleen
dc.contributor.authorSibson, Rachaelen
dc.contributor.authorSivasubramaniam, Selvarajen
dc.contributor.authorMeakin, Judith R.en
dc.contributor.authorGreig, Carolyn A.en
dc.contributor.authorAspden, Richard M.en
dc.contributor.authorThies, Franken
dc.contributor.authorJeromson, Stewarten
dc.contributor.authorHamilton, D Leeen
dc.contributor.authorSpeakman, John R.en
dc.contributor.authorHambly, Catherineen
dc.contributor.authorMangoni, Arduino A.en
dc.contributor.authorPreston, Thomasen
dc.contributor.authorGray, Stuart R.en
dc.date.acceptance2016-10-13en
dc.date.accessioned2017-08-10T11:28:18Z
dc.date.available2017-08-10T11:28:18Z
dc.date.issued2016-11-16
dc.descriptionOpen Access articleen
dc.description.abstractBackground: Resistance exercise increases muscle mass and function in older adults, but responses are attenuated compared with younger people. Data suggest that long-chain n–3 polyunsaturated fatty acids (PUFAs) may enhance adaptations to resistance exercise in older women. To our knowledge, this possibility has not been investigated in men. Objective: We sought to determine the effects of long-chain n–3 PUFA supplementation on resistance exercise training–induced increases in muscle mass and function and whether these effects differ between older men and women. Design: Fifty men and women [men: n = 27,mean 6 SD age: 70.6 6 4.5 y, mean 6 SD body mass index (BMI; in kg/m2), 25.6 6 4.2; women: n = 23, mean 6 SD age: 70.7 6 3.3 y, mean 6 SD BMI: 25.3 6 4.7] were randomly assigned to either long-chain n–3 PUFA (n = 23; 3 g fish oil/d) or placebo (n = 27; 3 g safflower oil/d) and participated in lower-limb resistance exercise training twice weekly for 18 wk. Muscle size, strength, and quality (strength per unit muscle area), functional abilities, and circulating metabolic and inflammatory markers were measured before and after the intervention. Results: Maximal isometric torque increased after exercise training to a greater (P , 0.05) extent in the long-chain n–3 PUFA group than in the placebo group in women, with no differences (P . 0.05) between groups in men. In both sexes, the effect of exercise training on maximal isokinetic torque at 30, 90, and 2408 s21, 4-m walk time, chair-rise time, muscle anatomic cross-sectional area, and muscle fat did not differ (P . 0.05) between groups. There was a greater (P , 0.05) increase in muscle quality in women after exercise training in the long-chain n–3 PUFA group than in the placebo group, with no such differences in men (P . 0.05). Long-chain n–3 PUFAs resulted in a greater decrease (P , 0.05) than the placebo in plasma triglyceride concentrations in both sexes, with no differences (P . 0.05) in glucose, insulin, or inflammatory markers. Conclusion: Long-chain n–3 PUFA supplementation augments increases in muscle function and quality in older women but not in older men after resistance exercise training.en
dc.funderBBSRCen
dc.identifier.citationDa Boit, M. et al. (2016) Sex differences in the effect of fish-oil supplementation on the adaptive response to resistance exercise training in older people: A randomized controlled trial. The American Journal of Clinical Nutrition, 105 (1), pp. 151-158en
dc.identifier.doihttps://doi.org/10.3945/ajcn.116.140780
dc.identifier.urihttp://hdl.handle.net/2086/14408
dc.language.isoenen
dc.peerreviewedYesen
dc.projectid(BB/J015911/1)en
dc.publisherAmerican Society for Nutritionen
dc.researchinstituteInstitute for Allied Health Sciences Researchen
dc.titleSex differences in the effect of fish-oil supplementation on the adaptive response to resistance exercise training in older people: A randomized controlled trialen
dc.typeArticleen

Files

License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.2 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

School of Allied Health Sciences