The effect of climbing chalk powder on the infectivity of human coronavirus OC43

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dc.cclicenceCC-BY-NCen
dc.contributor.authorOwen, Lucy
dc.contributor.authorLaird, Katie
dc.contributor.authorShivkumar, Maitreyi
dc.date.acceptance2021-02-18
dc.date.accessioned2021-03-04T09:17:38Z
dc.date.available2021-03-04T09:17:38Z
dc.date.issued2021-02-22
dc.descriptionThe file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link. Open access article.en
dc.description.abstractThere does not appear to be any studies in the published literature on the stability of SARS-CoV-2 within climbing chalk powder (magnesium carbonate and/or calcium carbonate), which has been hypothesized to pose a potential risk of fomite transmission of coronavirus disease 2019 (COVID-19) within climbing gyms. The aim of this study was to determine the infectivity of a model human coronavirus HCoV-OC43 in the presence of climbing chalk powder on a dry plastic surface. The stability of HCoV-OC43 on a plastic surface dusted with climbing chalk powders (magnesium carbonate, calcium carbonate or a blended chalk) was determined by titration on BHK-21 fibroblast cells. No chalk and no virus controls were included. HCoV-OC43 was stable on the plastic surface for 48 h. The stability of HCoV-OC43 was significantly (P≤0.05) reduced in the presence of magnesium carbonate, calcium carbonate and the chalk blend; the infectivity was reduced by ≥2.29 log10 50% tissue culture infective dose (TCID50) immediately upon on contact and by ≥2.46 log10 TCID50 within 1 h of contact. These findings suggest that the infectivity of coronaviruses is reduced by climbing chalk, limiting the risk of potential fomite transmission.en
dc.funderOther external funder (please detail below)en
dc.funder.otherAssociation of British Climbing Wallsen
dc.funder.otherThe Warehouse Climbing Centre Gloucesteren
dc.funder.otherLakeland Climbing Centreen
dc.identifier.citationOwen, L., Laird, K. and Shivkumar, M. (2021) The effect of climbing chalk powder on the infectivity of human coronavirus OC43. Letters in Applied Microbiology.en
dc.identifier.doihttps://doi.org/10.1111/lam.13466
dc.identifier.issn0266-8254
dc.identifier.urihttps://dora.dmu.ac.uk/handle/2086/20673
dc.language.isoenen
dc.peerreviewedYesen
dc.publisherWileyen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.subjecthuman coronavirus OC43en
dc.subjectcalcium carbonateen
dc.subjectmagnesium carbonateen
dc.subjectclimbing chalken
dc.subjectinfectivityen
dc.subjectTCID50en
dc.titleThe effect of climbing chalk powder on the infectivity of human coronavirus OC43en
dc.typeArticleen

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