Simultaneous Detection of Controlled Substances in Wastewater

Date

2013-04-18

Advisors

Journal Title

Journal ISSN

ISSN

Volume Title

Publisher

Royal Society of Chemistry

Type

Article

Peer reviewed

Yes

Abstract

his study presents a method of simultaneous detection of both traditional and newly emerged drugs of abuse in wastewater. The method is based on solid phase extraction and gas chromatography-mass spectrometry analysis. This analytical method separates 25 drugs from different classes including amphetamines, cathinones, tropane alkaloids, piperazines plus ketamine, amitriptyline, diazepam and morphine. In addition, newer compounds (methcathinone, mephedrone, butylone), and isomers (1-(2-methoxyphenyl) piperazine, 1-(4-methoxyphenyl) piperazine; 1-(2-flurophenyl) piperazine, 1-(4-flurophenyl) piperazine; 1-(3-trifluoromethylphenyl) piperazine, 1-(4-trifluoromethylphenyl) piperazine) have been separated, with greater sensitivity (×100 order of magnitude). This work reports the detection of butylone, mephedrone, 1-(4-methoxyphenyl) piperazine, 1-(2-flurophenyl) piperazine and 1-methyl-4-benzylpiperazine for the first time in waste water. This suggests that with changes in drug use patterns, constant monitoring of waste water entering treatment plants should be carried out and treatment processes need to be put in place for their removal.

Description

Researched with partners from Anglia Ruskin University

Keywords

GC-MS, newly emerging drugs, Waste water, Environmental forensic analysis

Citation

Mewnesongole, E., Gautam, L., Hall, S., Waterhouse, J., and Cole, M.D. (2013) Simultaneous Detection of Controlled Substances in Wastewater. Analytical Methods, 5, pp. 3248-3254

Rights

Research Institute

Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)