High Throughput Engineering and Use of Multi-Fiber Composite Matrices for Controlled Active Release

Abstract

A tri-compartment centrifugal electrospinning system (TCCES) was designed and used to fabricate multiple fiber membranes (from individual polyvinyl pyrrolidone (PVP), thermoplastic polyurethane (TPU) and poly-methyl methacrylate (PMMA) fibers). Controlled engineering of membrane composition presents opportunities to control mechanical and water contact angle characteristics. Furthermore, control on drug release rate is achieved based on active hosting fiber type contributing towards the overall membrane. The current system enables a high degree of alignment, production rate and variations to composition, indicating clear potential in biomedical fields requiring the use of encapsulated or embedded drug in membrane materials.

Description

The file attached to this record is the author's final peer reviewed version. The Publisher's final version can be found by following the DOI link.

Keywords

centrifugal electrospinning, composite fibers, alignment, regulation, drug release

Citation

Wang, L. et al. (2018) High Throughput Engineering and Use of Multi-Fiber Composite Matrices for Controlled Active Release. materials today communication, 17, pp. 53-59

Rights

Research Institute

Leicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)