The application of gene expression profiling in predictions of occult lymph node metastasis in colorectal cancer patients

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dc.cclicenceCC-BY-NCen
dc.contributor.authorAsadzadeh-Aghdaei, H.en
dc.contributor.authorZali, M. R.en
dc.contributor.authorBonab, Maziar Ashrafianen
dc.contributor.authorMcClellan, J.en
dc.contributor.authorYoung, Christopher N. J.en
dc.contributor.authorAnaraki, F.en
dc.contributor.authorNazemalhosseini-Mojarad, Een
dc.contributor.authorLarki, P.en
dc.contributor.authorGharib, E.en
dc.contributor.authorPeyravian, N.en
dc.date.acceptance2018-02-03en
dc.date.accessioned2018-03-29T13:57:10Z
dc.date.available2018-03-29T13:57:10Z
dc.date.issued2018-02-13
dc.description.abstractA key factor in determining the likely outcome for a patient with colorectal cancer is whether or not the tumour has metastasised to the lymph nodes, information which is also important in assessing any possibilities of lymph node resection so as to improve survival. In this review we perform a wide range assessment of literature relating to recent developments in gene expression profiling (GEP) of the primary tumour, to determine their utility in assessing node status. A set of characteristic genes seems to be involved in the prediction of lymph node metastasis (LNM) in colorectal patients. Hence, GEP is applicable in personalised/individualised/tailored therapies and provides insights into developing novel therapeutic targets. Not only is GEP useful in prediction of LNM, but also allows classification based on differences such as sample size, target gene expression and examination method.en
dc.funderBasic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Live Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iranen
dc.identifier.citationPeyravian, N. et al., 2018. The Application of Gene Expression Profiling in Predictions of Occult Lymph Node Metastasis in Colorectal Cancer Patients. Biomedicines, 6(1), p.27.en
dc.identifier.doihttps://doi.org/10.3390/biomedicines6010027
dc.identifier.issn2227-9059
dc.identifier.urihttp://hdl.handle.net/2086/15710
dc.language.isoenen
dc.peerreviewedYesen
dc.projectidN/Aen
dc.publisherMDPIen
dc.researchgroupPharmacology and Neuroscience Research Groupen
dc.researchinstituteLeicester Institute for Pharmaceutical Innovation - From Molecules to Practice (LIPI)en
dc.subjectColorectal cancer (CRC)en
dc.subjectLymph node metastasis (LNM)en
dc.subjectGene expression profiling (GEP)en
dc.titleThe application of gene expression profiling in predictions of occult lymph node metastasis in colorectal cancer patientsen
dc.typeArticleen

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